Emergency response to radiological and nuclear accidents and incidents.

British Journal of Haematology
Robert Peter GaleShahrukh K Hashmi

Abstract

Bone marrow damage is an important consequence of exposure to acute high-dose whole-body radiation. As such, haematologists can play an important role in managing this complication. However, these accident and incident scenarios are complex and often involve injuries to other organs and tissues from heat, projectiles and chemicals. In the case of a large-scale event there will likely be severe infrastructure disruptions and injury or death to medical personnel. Accurate estimates of dose and uniformity of exposure are needed to intelligently direct appropriate interventions, which range from antibiotics, antifungals and anti-virus drugs, molecularly-cloned haematopoietic growth factors and, in rare instances, haematopoietic cell transplants. These therapies are ones that haematologists often use in the context of anti-cancer therapy, especially therapy of haematological cancers like leukaemia. However, most haematologists have little knowledge of radiation biology and should consider updating this aspect of their expertise in continuing medical education. As in other areas of medicine, prevention is better than cure and haematologists should be active in decreasing risks of a nuclear war.

References

Jun 16, 2004·Annals of Internal Medicine·Jamie K WaselenkoUNKNOWN Strategic National Stockpile Radiation Working Group
Jun 2, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Daniel WeisdorfDennis Confer
Sep 11, 2008·Disaster Medicine and Public Health Preparedness·E Brooke LernerRobert E O'Connor
Mar 10, 2009·Radiation Research·Eugene DemidenkoHarold M Swartz
Mar 22, 2011·Disaster Medicine and Public Health Preparedness·Andrea L DiCarloDavid M Weinstock
Apr 22, 2011·The New England Journal of Medicine·John P ChristodouleasEli Glatstein
Oct 31, 2015·Radiation Protection Dosimetry·S Sholom, S W S McKeever
Oct 26, 2016·International Journal of Radiation Biology·Andrzej WojcikUlrike Kulka
Oct 6, 2017·Radiation Protection Dosimetry·Elizabeth A AinsburyFrancois Trompier
Mar 29, 2018·The New England Journal of Medicine·Robert P Gale, James O Armitage

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Citations

Mar 3, 2021·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Robert Peter Gale
Jul 29, 2021·Revista brasileira de enfermagem·Israel Baptista de Souza BorgesAlexandre Barbosa de Oliveira
Aug 18, 2021·International Journal of Radiation Biology·Vijay K Singh, Thomas M Seed
Sep 24, 2021·International Journal of Radiation Biology·Vijay K SinghMichael D Kaytor

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