Emergent and evolving antimicrobial resistance cassettes in community-associated fusidic acid and meticillin-resistant Staphylococcus aureus

International Journal of Antimicrobial Agents
Matthew J EllingtonSharon J Peacock

Abstract

Fusidic acid is a topical and systemic antimicrobial used for the treatment of staphylococcal infections in hospitals and the community. Sales of fusidic acid and resistance rates among meticillin-resistant Staphylococcus aureus (MRSA) doubled between 1990 and 2001. For the following decade, fusidic acid resistance rates among isolates from Addenbrooke's Hospital (Cambridge, UK) were compared with national resistance rates from MRSA bacteraemia surveillance data and with antimicrobial sales data. Sales of fusidic acid remained relatively constant between 2002 and 2012, whilst fusidic acid resistance increased two- and four-fold in MRSA bacteraemias nationally and in MRSA isolates from Cambridge, respectively. A subgroup of MRSA resistant only to fusidic acid increased after 2006 by 5-fold amongst bacteraemias nationally and 17-fold (to 7.7% in 2012) amongst Cambridge MRSA isolates. All of the available local isolates from 2011 to 2012 (n=23) were acquired in the community, were not related epidemiologically and belonged to multilocus sequence typing (MLST) groups ST1, 5, 8, 45 or 149 as revealed from analysis of whole-genome sequence data. All harboured the fusC gene on one of six distinct staphylococcal cassette chromosome (SC...Continue Reading

References

Sep 2, 1978·British Medical Journal
Oct 21, 1999·International Journal of Antimicrobial Agents·D Spelman
Sep 21, 2002·Lancet·David LivermorePeter Stephens
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Matthew T G HoldenJulian Parkhill
Apr 9, 2005·The New England Journal of Medicine·Scott K FridkinUNKNOWN Active Bacterial Core Surveillance Program of the Emerging Infections Program Network
Nov 17, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F J CookeN M Brown
Apr 3, 2010·British Medical Bulletin·Fiona J Cooke, Nicholas M Brown
May 13, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David J FarrellIan Chopra
Aug 5, 2011·Genome Biology and Evolution·Deborah C HoltPhilip M Giffard
Sep 17, 2011·The Journal of Antimicrobial Chemotherapy·J M AndrewsUNKNOWN BSAC Working Party on Susceptibility Testing
May 23, 2012·International Journal of Antimicrobial Agents·Jiun-Ling WangPo-Ren Hsueh
Oct 10, 2012·Current Opinion in Microbiology·José R MediavillaBarry N Kreiswirth
Mar 19, 2013·International Journal of Medical Microbiology : IJMM·Anna C Shore, David C Coleman
Aug 13, 2013·Journal of Epidemiology and Global Health·Jeanesse ScerriMichael A Borg
Sep 21, 2013·Emerging Infectious Diseases·Laura J ShallcrossAndrew C Hayward
Apr 23, 2014·Proceedings of the National Academy of Sciences of the United States of America·Anne-Catrin UhlemannFranklin D Lowy
Aug 21, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Deborah A WilliamsonJohn D Fraser

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Citations

Sep 12, 2015·ACS Applied Materials & Interfaces·Malte GrünerCristian A Strassert
Apr 28, 2016·Expert Review of Vaccines·Gustavo H DayanAnnaliesa S Anderson
Jun 27, 2017·International Journal of Surgery·Paul Lorenz BigliardiMartin Anthony Villa
Jun 9, 2017·Clinical Microbiology Reviews·Deborah A WilliamsonBenjamin P Howden
Jan 9, 2020·Microbial Genomics·Stefano G GiulieriDeborah A Williamson
May 21, 2020·The Journal of Infectious Diseases·Jennifer L GuthrieUNKNOWN Ontario CNISP Hospital Investigators
Jan 18, 2019·Acta Biomaterialia Odontologica Scandinavica·Tamer TüzünerJohn W Nicholson
Aug 15, 2019·Implementation Science : IS·Nina Van GoethemAnnie Robert
Oct 23, 2020·Journal of Clinical Microbiology·N EffelsbergA Mellmann
May 3, 2021·Antimicrobial Resistance and Infection Control·Bahareh HajikhaniMasoud Dadashi

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Methods Mentioned

BETA
PCR
dissect

Software Mentioned

Artemis
RAxML

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