Emergent Elements of Inspiratory Rhythmogenesis: Network Synchronization and Synchrony Propagation

Neuron
Sufyan Ashhad, Jack L Feldman

Abstract

We assessed the mechanism of mammalian breathing rhythmogenesis in the preBötzinger complex (preBötC) in vitro, where experimental tests remain inconsistent with hypotheses of canonical rhythmogenic cellular or synaptic mechanisms, i.e., pacemaker neurons or inhibition. Under rhythmic conditions, in each cycle, an inspiratory burst emerges as (presumptive) preBötC rhythmogenic neurons transition from aperiodic uncorrelated population spike activity to become increasingly synchronized during preinspiration (for ∼50-500 ms), which can trigger inspiratory bursts that propagate to motoneurons. In nonrhythmic conditions, antagonizing GABAA receptors can initiate this synchronization while inducing a higher conductance state in nonrhythmogenic preBötC output neurons. Our analyses uncover salient features of preBötC network dynamics where inspiratory bursts arise when and only when the preBötC rhythmogenic subpopulation strongly synchronizes to drive output neurons. Furthermore, downstream propagation of preBötC network activity, ultimately to motoneurons, is dependent on the strength of input synchrony onto preBötC output neurons exemplifying synchronous propagation of network activity.

References

Dec 22, 1990·The Journal of Comparative Neurology·H H EllenbergerH G Goshgarian
Sep 1, 1991·Journal of Neurophysiology·C N ChristakosC F Shaw
Jan 1, 1989·Annals of the New York Academy of Sciences·J L Feldman, J C Smith
Apr 1, 1986·The Journal of Physiology·R Miles, R K Wong
Jul 26, 1974·Brain Research·R A Mitchell, D A Herbert
May 1, 1980·Journal of Neurophysiology·J L FeldmanM I Cohen
Dec 1, 1993·Scientific American·S H Strogatz, I Stewart
Aug 15, 1997·Neural Computation·M L Hines, N T Carnevale
Apr 9, 1999·Nature Neuroscience·C F Stevens, A M Zador
Jun 14, 2002·Neuron·Christopher A Del NegroJack L Feldman
Jul 11, 2002·Respiratory Physiology & Neurobiology·Gregory D Funk, Marjorie A Parkis
Sep 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Marlene BartosPeter Jonas
Oct 26, 2002·Neuroscience Letters·Jijiang WangDavid Mendelowitz
May 14, 2003·Neuron·Simon J Mitchell, R Angus Silver
Sep 3, 2003·Nature Reviews. Neuroscience·Alain DestexheDenis Paré
Jun 26, 2004·Science·György Buzsáki, Andreas Draguhn
Jan 14, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christopher A Del NegroJack L Feldman
Nov 24, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Asa Wallén-MackenzieKlas Kullander
Feb 3, 2007·The Journal of Physiology·Ryland W PaceChristopher A Del Negro
Nov 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Steffen WittmeierChi-Sang Poon
Feb 25, 2009·Pflügers Archiv : European journal of physiology·Stefan M WinterSwen Hülsmann
Mar 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Consuelo Morgado-ValleJack L Feldman
Mar 18, 2010·The Journal of Comparative Neurology·Wenbin TanJack L Feldman
Aug 4, 2010·Nature Neuroscience·Julien BouvierGilles Fortin
Nov 5, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paul A GrayChristopher A Del Negro
Mar 11, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fernando R FernandezJohn A White
Sep 21, 2012·Journal of Neurophysiology·Michael S Carroll, Jan-Marino Ramirez

❮ Previous
Next ❯

Citations

Jun 17, 2020·Experimental Physiology·Michael George Zaki Ghali
Jul 22, 2020·Physical Review. E·Mihai BibireataAlex J Levine
Oct 15, 2020·Physiology·Barbara PalkovicAstrid G Stucke
Jan 12, 2021·Journal of Neurophysiology·Thiago S MoreiraAna C Takakura
Jun 24, 2021·Physiology·Ralph Lydic, Helen A Baghdoyan
Jul 31, 2021·Respiratory Physiology & Neurobiology·Donatella MutoloElenia Cinelli
Aug 5, 2021·Cell Reports·Dino DvorakAndré Antonio Fenton

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.