Emergent properties during dorsal closure in Drosophila morphogenesis.

Physical Biology
Xomalin G PeraltaGlenn S Edwards

Abstract

Dorsal closure is an essential stage of Drosophila development that is a model system for research in morphogenesis and biological physics. Dorsal closure involves an orchestrated interplay between gene expression and cell activities that produce shape changes, exert forces and mediate tissue dynamics. We investigate the dynamics of dorsal closure based on confocal microscopic measurements of cell shortening in living embryos. During the mid-stages of dorsal closure we find that there are fluctuations in the width of the leading edge cells but the time-averaged analysis of measurements indicate that there is essentially no net shortening of cells in the bulk of the leading edge, that contraction predominantly occurs at the canthi as part of the process for zipping together the two leading edges of epidermis and that the rate constant for zipping correlates with the rate of movement of the leading edges. We characterize emergent properties that regulate dorsal closure, i.e., a velocity governor and the coordination and synchronization of tissue dynamics.

References

Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A J MacKrellJ H Fessler
Feb 27, 1999·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·F Agnès, S Noselli
Sep 2, 1999·Current Biology : CB·D P Kiehart
Apr 18, 2000·The Journal of Cell Biology·D P KiehartR A Montague
Jul 12, 2002·Developmental Cell·Antonio JacintoPaul Martin
Jul 31, 2002·Differentiation; Research in Biological Diversity·Nicholas Harden
Oct 29, 2002·Nature Cell Biology·William WoodPaul Martin
Apr 16, 2003·Differentiation; Research in Biological Diversity·Ray KellerDavid R Shook
Mar 19, 2004·Current Biology : CB·Maithreyi Narasimha, Nicholas H Brown
Jun 16, 2004·Development·Paul Martin, Susan M Parkhurst

❮ Previous
Next ❯

Citations

Sep 21, 2013·Nature Reviews. Genetics·Callie Johnson Miller, Lance A Davidson
Sep 20, 2008·Science·Yusuke ToyamaGlenn S Edwards
May 1, 2009·Development·Nicole GorfinkielAlfonso Martinez Arias
May 1, 2009·HFSP Journal·Alice Rodriguez-DiazDaniel P Kiehart
Jun 2, 2010·HFSP Journal·Anita T LaytonStephanos Venakides
Sep 29, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yaiza Belacortu, Nuria Paricio
Jun 14, 2012·Birth Defects Research. Part C, Embryo Today : Reviews·Matthew A WyczalkowskiLarry A Taber
Dec 17, 2010·Genesis : the Journal of Genetics and Development·Nicole GorfinkielGuy B Blanchard
Oct 31, 2012·Genesis : the Journal of Genetics and Development·Luis Daniel Ríos-Barrera, Juan Rafael Riesgo-Escovar
Oct 11, 2011·Current Opinion in Genetics & Development·Stephan W Grill
Apr 28, 2009·The International Journal of Biochemistry & Cell Biology·Lance DavidsonJian Zhou
Mar 13, 2012·Biophysical Journal·Adam SokolowGlenn S Edwards
Oct 31, 2009·Developmental Biology·Adam C Martin
Aug 16, 2016·Current Biology : CB·Yusuke HaraYusuke Toyama
Nov 1, 2016·Molecular Biology of the Cell·Heng LuGlenn S Edwards
Oct 11, 2017·Annual Review of Cell and Developmental Biology·Daniel P KiehartGlenn S Edwards

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.