PMID: 9449011Feb 4, 1998Paper

Emergent properties of neural systems: how focal molecular neurobiological alterations can affect behavior

Development and Psychopathology
R M Post, S R Weiss

Abstract

Whereas the basic wiring diagram of the mammalian central nervous system (CNS) is genetically preprogramed, its fine tuning throughout different phases of infancy, childhood, and adulthood are highly experience dependent. The potential neurobiological mechanisms and behavioral effects of such experience-dependent neuroplasticity as a function of stage of development are outlined. A basic thesis of this paper is that mechanisms involved in neuronal learning and memory, such as long-term potentiation (LTP) and long-term depression (LTD), are used and reused not only in the sculpting of the CNS in the initial establishment of connections, but also again in the molding of personality and behavior based on experience. It is postulated that for higher order processes such as emotional memory, such neuroplasticity is occurring at increasingly larger numbers of synapses and cell assemblies with increasing mechanistic complexity and self-organization. Just as overexcitation or deprivation can profoundly affect the development of the visual system, it is postulated that similar phenomena exist in the neural substrates of emotional and cognitive development. In addition, a secondary and potentially more widespread series of ramifications ...Continue Reading

Citations

Jun 1, 1999·Biological Psychiatry·W KayeK Gendall
Apr 23, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A BacciM Matteoli
Jan 30, 2003·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Aaron W GrossmanWilliam T Greenough
Feb 6, 2007·The Journal of the American Academy of Psychoanalysis and Dynamic Psychiatry·Emanuela Mundo
Mar 9, 2007·Biological Psychology·Mats LarssonHåkan Stattin
Feb 9, 2000·Vision Research·V PorciattiL Maffei
Aug 28, 2010·American Journal of Psychoanalysis·Brad Bowins
Mar 27, 2003·The Australian and New Zealand Journal of Psychiatry·Josephine Beatson, Suzanna Taryan
Jun 23, 2005·Journal of Clinical and Experimental Neuropsychology·Scott A LangeneckerStanley Berent
Jan 9, 2008·Journal of Integrative Neuroscience·Angela Alessia Bruzzo, Ram Lakhan Pandey Vimal
Apr 24, 2008·Journal of Integrative Neuroscience·Ram Lakhan Pandey Vimal

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