Emerging advances in P-glycoprotein inhibitory nanomaterials for drug delivery

Expert Opinion on Drug Delivery
Longfa KouRuijie Chen

Abstract

P-glycoprotein 1 (P-gp) pumps out many foreign/toxic substances out of the cells, including intracellular drugs, causing multidrug resistance (MDR) and chemotherapy failure. It remains quite a challenge to inhibit P-gp to combat MDR and improve cellular bioavailability since it requires efficient inhibitors along with adequate formulation strategy. Lately, nanocarriers are gaining much attention and form an attractive platform for delivering drugs into cells. Therefore, nanomaterials act as direct inhibitors of P-gp will be an attractive alternative to overcome MDR. This paper reviews the most recent advances on those nanomaterials that are currently in the developmental stage and has proven useful to treat P-gp involved MDR. Also, we emphasize those emerging multifunctional nanomaterials that can construct 'smart' carriers for both tumor targeting and P-gp inhibition. Furthermore, the mechanisms behind P-gp inhibition and the nanoformulation strategies for drug delivery are also discussed. In light of these updated reports, this review here seeks to suggest an alternative for the chemoresistant cases, and also bring about new thoughts on tackling P-gp concerned drug delivery issues. New advances in nanomaterials with P-gp inhi...Continue Reading

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Citations

Dec 19, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Qing YaoYing-Zheng Zhao
Oct 30, 2020·Drug Delivery·Xue JiangLongfa Kou
Jan 17, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Priyanshi Patel, Mitali Patel
Dec 18, 2020·Frontiers in Molecular Biosciences·Xiaoliang ChengWei-En Yuan
Feb 23, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Xu ChengRupei Tang
May 7, 2020·Asian Journal of Pharmaceutical Sciences·Longfa KouRuijie Chen
May 16, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shangui LiuGuangxi Zhai
Jan 19, 2022·Pancreas·Yue PanGary Guishan Xiao

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