Emerging applications of exosomes in cancer therapeutics and diagnostics.

Bioengineering & Translational Medicine
Sahil InamdarKaushal Rege

Abstract

Exosomes are nanoscale extracellular vesicles that are shed from different cells in the body. Exosomes encapsulate several biomolecules including lipids, proteins, and nucleic acids, and can therefore play a key role in cellular communication. These vesicles can be isolated from different body fluids and their small sizes make them attractive in various biomedical applications. Here, we review state-of-the art approaches in exosome isolation and purification, and describe their potential use in cancer vaccines, drug delivery, and diagnostics.

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Jun 18, 2017·International Journal of Molecular Sciences·Maike E van HezelNicole P Juffermans
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Methods Mentioned

BETA
density gradient centrifugation
fluorescence
confocal microscopy
PCR
biopsy

Software Mentioned

ExoQuick

Related Concepts

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Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

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