Emerging applications of upconverting nanoparticles in intestinal infection and colorectal cancer

International Journal of Nanomedicine
Raminder SinghSilvia Melgar

Abstract

Colorectal cancer is the abnormal growth of cells in colon or rectum. Recent findings have acknowledged the role of bacterial infection and chronic inflammation in colorectal cancer initiation and progression. In order to detect and treat precancerous lesions, new tools are required, which may help to prevent or identify colorectal cancer at an early stage. To date, several different screening tests are available, including endoscopy, stool-based blood tests, and radiology-based tests. However, these analyses either lack sensitivity or are of an invasive nature. The use of fluorescently labeled probes can increase the detection sensitivity. However, autofluorescence, photobleaching, and photodamage are commonly encountered problems with fluorescence imaging. Upconverting nanoparticles (UCNPs) are recently developed lanthanide-doped nanocrystals that can be used as light-triggered luminescent probes and in drug delivery systems. In this review, we comprehensively summarize the recent developments and address future prospects of UCNP-based applications for diagnostics and therapeutic approaches associated with intestinal infection and colorectal cancer.

Citations

Aug 23, 2020·Cancers·Siang-Siang ChewLearn-Han Lee
Dec 5, 2019·Frontiers in Oncology·George Mattheolabakis, Constantinos M Mikelis
Jul 1, 2020·International Journal of Radiation Biology·Georgios KareliotisAlexandros G Georgakilas
May 6, 2021·Biomaterials Science·Maria José SilveiraBruno Sarmento
Jun 24, 2021·Critical Reviews in Food Science and Nutrition·Deshmukh Abdul HakeemHongli Wen
Feb 19, 2020·Methods and Applications in Fluorescence·Daria V PominovaVictor B Loschenov

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Methods Mentioned

BETA
fluorescence imaging
imaging techniques
biopsy
fluorescence
FRET

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