Emerging Association Between Parathyroid Hormone and Anemia in Hemodialysis Patients

Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
Motoko TanakaMasafumi Fukagawa

Abstract

Anemia is a common complication of chronic kidney disease (CKD). There are various causes of renal anemia such as decreased production of erythropoietin, resistance to erythropoietin, shortened survival of red blood cells, and bone marrow fibrosis. Secondary hyperparathyroidism (SHPT) is a less recognized, but potentially significant cause of renal anemia in CKD patients. Parathyroid hormone (PTH) has been regarded as a uremic toxin that has multiple adverse effects, and its elevated levels have been associated with renal anemia in hemodialysis patients. Moreover, recent clinical studies have shown that the treatment of SHPT using either vitamin D receptor activators, calcimimetics, or parathyroidectomy leads to improvement of anemia, supporting the role of PTH in renal anemia. Emerging data have also indicated the involvement of bone-derived fibroblast growth factor 23 in renal anemia. This review summarizes recent insights into the role of PTH in renal anemia and discusses the importance of treating SHPT in improving the control of renal anemia in hemodialysis patients.

References

Aug 1, 1979·Archives of Internal Medicine·G L Barbour
Nov 1, 1978·Archives of Internal Medicine·J ZingraffP Bordier
Jan 1, 1992·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M WashioM Fujishima
Oct 1, 1985·The Journal of Clinical Investigation·M AkmalS G Massry
Apr 1, 1982·The Journal of Clinical Investigation·E BoginJ Smith
Apr 1, 1981·Proceedings of the Society for Experimental Biology and Medicine·C D Dunn, D Trent
May 1, 1981·The Journal of Clinical Investigation·D MeytesS G Massry
Mar 1, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S AlbitarC Chuet
Aug 27, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A KomatsudaA B Miura
Oct 30, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S MandolfoE Imbasciati
May 10, 2001·Proceedings of the National Academy of Sciences of the United States of America·T ShimadaT Yamashita
Mar 29, 2002·American Journal of Surgery·Chikao YasunagaTadanobu Goya
Dec 20, 2003·Journal of the American Society of Nephrology : JASN·Diego BrancaccioMaurizio Gallieni
Apr 9, 2004·The New England Journal of Medicine·Geoffrey A BlockWilliam G Goodman
Jan 27, 2006·The Journal of Biological Chemistry·Hiroshi KurosuMakoto Kuro-o
Nov 7, 2006·Nature·Itaru UrakawaTakeyoshi Yamashita
Apr 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kamyar Kalantar-ZadehCsaba P Kovesdy
Jan 30, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Adam E GawedaGeorge R Aronoff
Feb 5, 2010·Kidney International·Neha M PatelMyles Wolf
Jul 7, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Masahiro KoizumiMasafumi Fukagawa
Jun 21, 2012·Nature Reviews. Nephrology·Hirotaka Komaba, Masafumi Fukagawa
Sep 1, 2012·Journal of the American Society of Nephrology : JASN·Jodie L Babitt, Herbert Y Lin
Feb 11, 2014·The Journal of Biological Chemistry·Lindsay M CoeDespina Sitara
Jun 11, 2015·Circulation·Sharon M MoeUNKNOWN Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) Trial Investigators*
Aug 13, 2015·Seminars in Dialysis·Hirotaka Komaba, Masafumi Fukagawa
Dec 19, 2015·Journal of the American Society of Nephrology : JASN·Dana C MiskulinDaniel E Weiner
Aug 9, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Rupal MehtaUNKNOWN CRIC Study Investigators

❮ Previous
Next ❯

Citations

Nov 10, 2018·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Masahide MizobuchiFumihiko Koiwa
May 28, 2020·Kidney Research and Clinical Practice·Eun Jeong KoByung Ha Chung
Mar 28, 2020·Journal of Clinical Medicine·Yi-Chou HouYuh-Feng Lin
Nov 20, 2019·Indian Journal of Endocrinology and Metabolism·Manju Chandran, Jiunn Wong
Feb 23, 2020·International Journal of Environmental Research and Public Health·Giorgina Barbara PiccoliNicola Panocchia
Oct 30, 2020·International Journal of Nephrology and Renovascular Disease·Elton Jonh Freitas SantosAlcione Miranda Dos Santos
Mar 30, 2021·Kidney International Supplements·Peter A McCullough
Aug 1, 2021·International Journal of Clinical Practice·Sheena Pramod, David S Goldfarb
Aug 11, 2021·Nutrients·Matteo BargagliPietro Manuel Ferraro
Aug 20, 2021·Curēus·Elmukhtar HabasAbdel-Naser Y Elzouki
Dec 5, 2021·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Eiko UedaKouichi Tamura

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.