Emerging Cancer Therapeutic Targets in Protein Homeostasis

The AAPS Journal
Prabhakar BastolaJeremy Chien

Abstract

Genomic aberrations inside malignant cells through copy number alterations, aneuploidy, and mutations can exacerbate misfolded and unfolded protein burden resulting in increased proteotoxic stress. Increased proteotoxic stress can be deleterious to malignant cells; therefore, these cells rely heavily on the protein quality control mechanisms for survival and proliferation. Components of the protein quality control, such as the unfolded protein response, heat shock proteins, autophagy, and the ubiquitin proteasome system, orchestrate a cascade of downstream events that allow the mitigation of the proteotoxic stress. This dependency makes components of the protein quality control mechanisms attractive targets in cancer therapeutics. In this review, we explore the components of the protein homeostasis especially focusing on the emerging cancer therapeutic agents/targets that are being actively pursued actively.

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Citations

Jan 4, 2019·Nature Cell Biology·Narendra Kumar Chunduri, Zuzana Storchová
Jul 31, 2019·Scientific Reports·Prabhakar BastolaJeremy Chien
Aug 23, 2020·Pharmaceutics·Prabhakar BastolaMatthew L Hirsch
Aug 28, 2020·Cancers·Claudio Brancolini, Luca Iuliano
Feb 23, 2020·Acta Pharmaceutica Sinica. B·Yang WangHaopeng Sun
Sep 29, 2019·Seminars in Cancer Biology·Derek B OienViji Shridhar
Mar 5, 2021·Emerging Topics in Life Sciences·Hong ZhangSarah Perrett
May 1, 2021·Frontiers in Molecular Biosciences·Xin ChenDaolin Tang

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Methods Mentioned

BETA
protein folding
xenografts
xenograft
nuclear translocation
acetylation
deubiquitination

Software Mentioned

Cleave

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