Emerging Candida species isolated from renal transplant recipients: Species distribution and susceptibility profiles

Microbial Pathogenesis
Kambiz DibaHamed Fakhim

Abstract

Candidiasis is a major challenge among renal transplant recipients (RTRs) worldwide and is associated with high morbidity and mortality rates. Fluconazole is the most commonly used agent for Candida infections. However, frequent relapse and treatment failure are still reported among patients affected with this infection. In the present study, Candida species obtained from RTRs were characterized based on conventional and molecular assays. Furthermore, the antifungal susceptibility profiles of these species were determined. This study was conducted on a total of 126 RTRs within 2012-2016. The patients were categorized according to the referenced diagnostic criteria. The identification of Candida species was accomplished based on conventional examination, assimilation profile test, and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The minimum inhibitory concentrations (MICs) of amphotericin B, fluconazole, itraconazole, voriconazole, posaconazole, and caspofungin were determined based on the guidelines of Clinical and Laboratory Standards Institute. The patients with Candida infection were diagnosed with urinary tract candidiasis (n = 17), peritonitis (n = 8), intra-abdominal candidiasis (n...Continue Reading

Citations

Sep 19, 2018·Antimicrobial Agents and Chemotherapy·Mahdi AbastabarHamid Badali
Dec 22, 2019·Journal of Fungi·Gustavo FontechaSharleen Braham
Jul 2, 2019·Frontiers in Microbiology·Linh Thi Truc PhamPopchai Ngamskulrungroj
Oct 2, 2019·Frontiers in Microbiology·Isis Regina Grenier CapociTerezinha Inez Estivalet Svidzinski
May 14, 2019·Frontiers in Microbiology·Jin-Yan WuJianping Xu

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