Emerging chemical and biological approaches for the preparation of discovery libraries

Drug Discovery Today
Grant E BoldtKim D Janda

Abstract

The term of combinatorial chemistry has come to embrace all types of small-molecule library strategies. In both academic and industrial settings, the development of many combinatorial techniques has been driven by a desire to generate diverse libraries of molecules. Recently, chemical approaches have been reported that range from alternative library design concepts to new synthetic procedures that allow for selective product formation in extremely short reaction times. Concurrently, biological techniques have made great strides by adapting naturally occurring strategies for library preparation and screening. With proper understanding of library design, combinatorial endeavors and molecular libraries will continue to impact on the development of the next generation of tools for modern medicine.

References

Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S Brenner, R A Lerner
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·I Huc, J M Lehn
Aug 24, 2000·Accounts of Chemical Research·P H Toy, K D Janda
Dec 29, 2000·Journal of Combinatorial Chemistry·A R Vaino, K D Janda
Feb 24, 2001·Chemistry : a European Journal·A KirschningR Wittenberg
Mar 29, 2001·Journal of Pharmacological and Toxicological Methods·C A Lipinski
May 2, 1997·The Journal of Organic Chemistry·Armido StuderDennis P. Curran
Oct 10, 2002·Chemical Reviews·Tobin J DickersonKim D Janda
Oct 10, 2002·Chemical Reviews·Jun-Ichi Yoshida, Kenichiro Itami
Oct 31, 2002·Nature Reviews. Drug Discovery·Steven V Ley, Ian R Baxendale
Nov 2, 2002·Angewandte Chemie·Carl Christoph TzschuckeRainer Haag
Oct 3, 2003·Chemistry & Biology·Frederic Fellouse, Kurt Deshayes
Oct 3, 2003·Chemistry & Biology·Thomas F WoiwodeSteven E Cwirla
Dec 16, 2003·Chemistry : a European Journal·Gerhard Jas, Andreas Kirschning
Dec 18, 2003·Drug Discovery Today·Hartmuth C Kolb, K Barry Sharpless
Dec 25, 2003·Angewandte Chemie·Martin D Burke, Stuart L Schreiber
Mar 9, 2004·Journal of Combinatorial Chemistry·Wen-Ben Yeh, Chung-Ming Sun
Mar 20, 2004·Science·Robert F Service
Apr 21, 2004·Nature Biotechnology·Samu MelkkoDario Neri
Apr 22, 2004·Journal of the American Chemical Society·Xiaoyu LiDavid R Liu
May 12, 2004·Combinatorial Chemistry & High Throughput Screening·Wen-Bing YehChung-Ming Sun
Jun 29, 2004·PLoS Biology·David R Halpin, Pehr B Harbury
Jul 13, 2004·Journal of Combinatorial Chemistry·Daniel JönssonMark Ladlow
Oct 21, 2004·Journal of the American Chemical Society·Jun YinChristopher T Walsh
Nov 24, 2004·Angewandte Chemie·C Oliver Kappe
Nov 27, 2004·Chemistry : a European Journal·Jeremy D CheesemanRomas J Kazlauskas
May 5, 2005·Journal of the American Chemical Society·Antoni KrasińskiHartmuth C Kolb
Jun 15, 2005·Angewandte Chemie·Hang Yin, Andrew D Hamilton
Aug 2, 2005·Nature Reviews. Drug Discovery·Gisbert Schneider, Uli Fechner

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Citations

Jun 15, 2007·Journal of Chromatography. a·André de VilliersPat Sandra
Sep 20, 2007·Journal of Combinatorial Chemistry·Roland E DolleWei Zhang
Aug 15, 2009·Chemical Reviews·Jianzhao LiuBen Zhong Tang

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