Emerging Chemodiversity and Stereoisomerism in Acyclic Mono- and Dichloroalkanes

Chemistry & Biodiversity
Bernard Testa

Abstract

The objective of this pen-and-paper study is to monitor the growth of structural complexity as a function of the number of heavy atoms. This is done here using simple chloroalkanes, the indices of structural complexity being the number of regioisomers and mainly stereoisomeric features. Following a previous work dealing with acyclic alkanes, the present study focuses on all acyclic monochloroalkanes from four heavy atoms (four regioisomers) to 10 heavy atoms (2 to 211 regioisomers, respectively). Similarly, all acyclic dichloroalkanes were drawn, ranging from five heavy atoms to nine heavy atoms (4 to 130 regioisomers, respectively). The first part of the work describes the nature and number of stereoisomeric features seen to emerge in molecular structures featuring one or more stereogenic centers. These molecular features include enantiomerism, diastereoisomerism, pseudoasymmetry, and meso-isomerism. The first appearance of chirality among the monochloro and dichloro homologs occurred in the families with five heavy atoms. Diastereoisomerism, meso-isomerism, and pseudoasymmetry appear in higher families of homologs. The second part of the article is an attempt to rationalize the appearance of regioisomers, stereogenic centers,...Continue Reading

References

Apr 30, 1999·Journal of the Experimental Analysis of Behavior·C P Shimp
Jan 12, 2007·Physical Chemistry Chemical Physics : PCCP·Claudio MorgadoXiao Shan
May 9, 2014·Chimerism·David Haig
Oct 11, 2014·Chemistry : a European Journal·Stephanie Kindt, Markus R Heinrich
May 26, 2017·Chirality·Oliver TrappJohn Caldwell

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