Emerging concepts in alcoholic hepatitis

World Journal of Hepatology
Phoenix Fung, Nikolaos Pyrsopoulos

Abstract

Severe alcoholic hepatitis is implicated as a costly, worldwide public health issue with high morbidity and mortality. The one-month survival for severe alcoholic hepatitis is low with mortality rates high as 30%-50%. Abstinence from alcohol is the recommended first-line treatment. Although corticosteroids remain as the current evidence based option for selected patients with discriminant function > 32, improvement of short-term survival rate may be the only benefit. Identification of individuals with risk factors for the development of severe alcoholic hepatitis may provide insight to the diverse clinical spectrum and prognosis of the disease. The understanding of the complex pathophysiologic processes of alcoholic hepatitis is the key to elucidating new therapeutic treatments. Newer research describes the use of gut microbiota modification, immune modulation, stimulation of liver regeneration, caspase inhibitors, farnesoid X receptors, and the extracorporeal liver assist device to aid in hepatocellular recovery. Liver transplantation can be considered as the last medical option for patients failing conventional medical interventions. Although the preliminary data is promising in patients with low risk of recividism, controver...Continue Reading

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Citations

Jun 9, 2018·Journal of Intensive Care Medicine·Michelle MaAhmet Gurakar
Nov 11, 2017·BMJ Case Reports·Cyriac Abby PhilipsPhilip Augustine
Jun 20, 2019·European Journal of Clinical Investigation·Donogh MaguireDonald C McMillan
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Sep 19, 2020·Curēus·Ted George O AchufusiKanish Mirchia
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Oct 13, 2020·Cellular & Molecular Immunology·Yongyan Chen, Zhigang Tian
Oct 13, 2020·United European Gastroenterology Journal
Sep 23, 2020·Pharmacology & Therapeutics·Maria Azparren-AnguloJuan M Falcon-Perez
Mar 9, 2021·Toxicology Reports·Vetriselvan SubramaniyanAnju Das
Jun 3, 2021·International Journal of Molecular Sciences·Szu-Yi LiuYin-Chou Hsu

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Methods Mentioned

BETA
biopsies
biopsy
blood draws

Software Mentioned

PREDICT

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