Emerging concepts in biliary repair and fibrosis

American Journal of Physiology. Gastrointestinal and Liver Physiology
Luca FabrisMario Strazzabosco

Abstract

Chronic diseases of the biliary tree (cholangiopathies) represent one of the major unmet needs in clinical hepatology and a significant knowledge gap in liver pathophysiology. The common theme in cholangiopathies is that the target of the disease is the biliary tree. After damage to the biliary epithelium, inflammatory changes stimulate a reparative response with proliferation of cholangiocytes and restoration of the biliary architecture, owing to the reactivation of a variety of morphogenetic signals. Chronic damage and inflammation will ultimately result in pathological repair with generation of biliary fibrosis and clinical progression of the disease. The hallmark of pathological biliary repair is the appearance of reactive ductular cells, a population of cholangiocyte-like epithelial cells of unclear and likely mixed origin that are able to orchestrate a complex process that involves a number of different cell types, under joint control of inflammatory and morphogenetic signals. Several questions remain open concerning the histogenesis of reactive ductular cells, their role in liver repair, their mechanism of activation, and the signals exchanged with the other cellular elements cooperating in the reparative process. This r...Continue Reading

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Citations

Oct 24, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nidhi Jalan-Sakrikar, Robert C Huebert
Nov 16, 2017·PloS One·Carola M MorellMario Strazzabosco
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Dec 7, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Iris E M de JongRobert J Porte
Jun 6, 2019·Nature Reviews. Gastroenterology & Hepatology·Luca FabrisMario Strazzabosco
May 10, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nidhi Jalan-SakrikarRobert C Huebert
Dec 14, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Maria Eugenia GuicciardiGregory J Gores
Mar 13, 2020·Seminars in Liver Disease·Luca FabrisGregory J Gores
Mar 5, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Adiba I AzadGregory J Gores
Mar 10, 2019·Nature Reviews. Gastroenterology & Hepatology·Jesus M BanalesGregory J Gores
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Aug 25, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Romina FiorottoMario Strazzabosco
Aug 17, 2019·International Journal of Molecular Sciences·Luca FabrisJoachim Mertens
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Jun 22, 2021·JHEP Reports : Innovation in Hepatology·Valeria MariottiMario Strazzabosco
Aug 8, 2021·Cells·Beatrice FogliaMaurizio Parola

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Methods Mentioned

BETA
nuclear translocation

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