Emerging drugs for alopecia areata: JAK inhibitors

Expert Opinion on Emerging Drugs
Matilde Iorizzo, Antonella Tosti

Abstract

Alopecia Areata is a common form of non-scarring hair loss that usually starts abruptly with a very high psychological impact. Due to the still not completely understood etiopathogenesis, at present there is no treatment that can induce a permanent remission and there is no drug approved for the treatment of this disorder. Areas covered: Leading existing treatment are briefly overviewed and then ongoing research on Janus Kinases Inhibitors is discussed, reviewing trials with oral and topical formulations so as new opportunities for other forms of alopecia, such as cicatricial alopecia. Expert opinion: JAK inhibitors represent a promise among alopecia treatments, but further studies are needed on long term safety. There is still no validated dosage for alopecia areata and the vehicles used for topical formulations seem not yet ideal in terms of skin penetration and reduced systemic absorption. Hopefully several studies are ongoing and we hope, in the near future, that JAK inhibitors will become part of the armamentarium to treat alopecia areata patients in terms of safety and costs.

References

Feb 1, 1996·International Journal of Dermatology·V K Sharma
Oct 20, 1998·Journal of the American Academy of Dermatology·A FriedliJ H Saurat
Nov 12, 1998·Journal of the American Academy of Dermatology·C K RokhsarK Washenik
Jul 2, 2003·Journal of the American Academy of Dermatology·Antonella TostiColombina Vincenzi
Aug 16, 2006·Journal of the American Academy of Dermatology·Antonella TostiMatilde Iorizzo
Oct 26, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·Antonella TostiMassimo Milani
Dec 29, 2010·International Journal of Trichology·Gurcharan Singh, Ms Lavanya
Apr 25, 2012·The British Journal of Dermatology·A G MessengerM Sladden
Jul 9, 2014·American Journal of Clinical Dermatology·Maria Hordinsky, Aline Donati
Sep 10, 2014·Nature Medicine·Sherrie J Divito, Thomas S Kupper
Dec 21, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alejandro V VillarinoJohn J O'Shea
Jul 3, 2015·EBioMedicine·Ali JabbariAbraham Zlotogorski
Jul 18, 2015·Journal of the American Academy of Dermatology·Thomas Waitao ChuJerry Shapiro
Nov 26, 2015·Science Advances·Sivan HarelAngela M Christiano
Dec 10, 2015·JAMA Dermatology·Brittany G CraiglowBrett A King
Apr 18, 2016·Journal of the American Academy of Dermatology·Sergio Vañó-GalvánPedro Jaén
Jun 1, 2016·Medical Hypotheses·Vito Di Lernia
Oct 7, 2016·PloS One·Ana Karina Alves de MedeirosJo Lambert
Nov 7, 2016·Journal of the American Academy of Dermatology·Brittany G CraiglowBrett A King
Nov 7, 2016·Journal of the American Academy of Dermatology·Lucy Y LiuBrett A King
Feb 1, 2017·Journal of the American Academy of Dermatology·William Damsky, Brett A King
Feb 9, 2017·Journal of the American Academy of Dermatology·Rony Shreberk-HassidimAbraham Zlotogorski
Jun 18, 2017·Journal of the American Academy of Dermatology·Cheryl B BayartRobert Sidbury
Jun 18, 2017·Journal of the American Academy of Dermatology·Yong Hyun JangDo Won Kim
Jul 19, 2017·Clinical Reviews in Allergy & Immunology·Ralph M Trüeb, Maria Fernanda Reis Gavazzoni Dias
Dec 16, 2017·Journal of the American Academy of Dermatology·Lauren C StrazzullaJerry Shapiro

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Citations

Jun 8, 2018·International Journal of Dermatology·Rokea A El-Azhary
Jan 16, 2019·Expert Opinion on Investigational Drugs·Jorge Ocampo-GarzaAntonella Tosti
Oct 16, 2018·Expert Opinion on Drug Safety·Hind M AlmohannaAntonella Tosti
Jan 7, 2021·Dermatologic Therapy·Özge AşkınServer Serdaroğlu
May 21, 2020·Molecular Pharmaceutics·Guang YangZhen Gu
Nov 4, 2021·Journal of Cosmetic Dermatology·Sahar Taha Hatif AldaffaieAli Abd Razzak Muhieldden

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