Emerging drugs for bronchiectasis: an update

Expert Opinion on Emerging Drugs
Anne B ChangLucas R Hoffman

Abstract

Recent research has confirmed the increasing burden of bronchiectasis, in affluent and developing countries. Bronchiectasis, the destruction and dilation of airways, is due to a variety of causes and is characterised by a self-perpetuating cycle of airway inflammation, infection and obstruction that results in substantial morbidity and mortality. Improved therapies that address these three components, and the diseases that both cause and result from bronchiectasis are required. In this review, we update our previous summary of the clinical features, pathophysiology and epidemiology of bronchiectasis among adults and children, highlighting the most recent advances in therapeutics. We discuss current treatment strategies and then identify key goals for future research on the causes and treatments of a variety of types of bronchiectasis. Bronchiectasis remains an orphan disease with respect to the development of new therapies. There has been progress in the recognition and studies but further research is now required on the pathogenesis, prevention, and treatment of bronchiectasis in order to decrease its high burden. Such advances will require a concerted, global effort to coordinate studies of both the pathophysiology and potent...Continue Reading

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Citations

Feb 4, 2016·Pediatric Pulmonology·Vikas GoyalAnne B Chang
Mar 17, 2016·Annual Review of Pathology·Rosemary J Boyton, Daniel M Altmann
May 26, 2017·Expert Review of Respiratory Medicine·Danielle F Wurzel, Anne B Chang
Sep 23, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Kate H Regan, Adam T Hill
Mar 22, 2019·Expert Opinion on Pharmacotherapy·Eun Lee, Soo-Jong Hong
Jun 28, 2019·American Journal of Respiratory and Critical Care Medicine·Pier-Valerio MariLuca Richeldi

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