Emerging drugs for premature ejaculation

Expert Opinion on Emerging Drugs
M D Waldinger

Abstract

Lifelong premature ejaculation (PE) is a frequent male sexual dysfunction and is thought to be mediated in part by disturbances of serotonergic (5-hydroxytryptamine; 5-HT) neurotransmission and ejaculation-mediating 5-HT receptors in the CNS. The aetiology of the dysfunction is unclear, but probably includes neurobiological and environmental factors. Lifelong PE is a syndrome characterised by a cluster of symptoms. Rapid ejaculations become manifest around the first sexual encounters in puberty or adolescence. Intravaginal ejaculation latency time usually occurs within 30-60 s, or maximally within 2 min after vaginal penetration, is present with nearly every sexual partner, and remains similar throughout life or may aggravate during ageing. The syndrome may lead to secondary psychological, sexual and relationship problems. Daily treatment with some selective serotonin re-uptake inhibitors (SSRIs) leads to strong ejaculation delay, but may be accompanied by side effects. New treatment with SSRIs with a short half-life (if approved) for on-demand use 1-2 h prior to coitus exerts less ejaculation-delaying effects than daily SSRI strategies. Animal studies have shown that strong, immediate ejaculation delay may be induced by the co...Continue Reading

References

Jan 1, 1992·International Journal of Psychiatry in Medicine·J S St Lawrence, S Madakasira
Jan 1, 1989·Journal of Sex & Marital Therapy·M L Godpodinoff
Jul 1, 1982·Andrologia·S M GirgisS El-Hermouzy
Oct 1, 1995·The Journal of Urology·M BerkovitchG Koren
Mar 27, 1995·Archives of Internal Medicine·S Ahmad
Sep 1, 1994·The American Journal of Psychiatry·M D WaldingerA H Zwinderman
Jan 1, 1993·Journal of Sex & Marital Therapy·R T SegravesE Maguire
Oct 1, 1996·The Journal of Urology·S M HaenselK T Kallan
Sep 5, 1998·International Clinical Psychopharmacology·B OlivierM D Waldinger
Nov 18, 1998·The Journal of Clinical Psychiatry·E H Rand
Feb 18, 1999·JAMA : the Journal of the American Medical Association·E O LaumannR C Rosen
Mar 19, 1999·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J MosB Olivier
May 18, 1999·Journal of Sex & Marital Therapy·D S StrassbergA K Slob
Dec 20, 1999·International Journal of Impotence Research·C G McMahon, K Touma
Jul 6, 2000·Pharmacology, Biochemistry, and Behavior·J L FrankC H Olson
Apr 21, 2001·International Journal of Impotence Research·I A Abdel-HamidA H El Gilany
Jun 17, 2003·Archives of Sexual Behavior·E Sandra Byers, Guy Grenier
Aug 21, 2003·Postgraduate Medicine·Kara E Ditto
Sep 25, 2003·Journal of Sex & Marital Therapy·T SymondsS Althof
Jun 18, 2004·The Journal of Urology·Drogo K MontagueUNKNOWN AUA Erectile Dysfunction Guideline Update Panel
Feb 15, 2005·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Cássio AndreoniRalph V Clayman
Feb 17, 2005·European Journal of Pharmacology·Trynke R de JongBerend Olivier
Mar 30, 2005·Expert Opinion on Drug Safety·Robert M WeinriebJames D Lewis
Apr 13, 2005·World Journal of Urology·Pierre Assalian
Jun 9, 2005·World Journal of Urology·Marcel D Waldinger, Berend Olivier
Aug 17, 2005·The European Journal of Neuroscience·Tommy PattijBerend Olivier
Oct 6, 2005·The Journal of Clinical Endocrinology and Metabolism·Cesare CaraniEmmanuele A Jannini

❮ Previous
Next ❯

Citations

Jan 6, 2011·Expert Opinion on Therapeutic Targets·Ibrahim A Abdel-HamidAndrea Salonia
Mar 17, 2007·The Journal of Sexual Medicine·Emad A SalemMario A Cleves
Jan 20, 2007·The Journal of Sexual Medicine·Trynke R de JongMarcel D Waldinger
Mar 29, 2008·The Journal of Sexual Medicine·Marcel D Waldinger, Dave H Schweitzer
Nov 7, 2007·The Urologic Clinics of North America·Allen D SeftelStanley E Althof
Mar 14, 2007·Drugs·Marcel D Waldinger
Jul 15, 2011·Pharmacological Reviews·Anders S KristensenUlrik Gether
Dec 7, 2019·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Soheila SiroosbakhtBijan Rezakhaniha

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.