Emerging Endotypes of Chronic Rhinosinusitis and Its Application to Precision Medicine

Allergy, Asthma & Immunology Research
Dae Woo Kim, Seong H Cho

Abstract

Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disease with various underlying pathophysiologic mechanisms which translate to endotypes, in contrast to clinical phenotypes or histological subtypes. Defining endotypes can help clinicians predict disease prognosis, select subjects suitable for a specific therapy, and assess risks for comorbid conditions, including asthma. Therefore, with recent advancement of biologicals in CRS clinical trials, endotyping can be a breakthrough in treating recalcitrant CRS. CRS is caused by dysregulated immunologic responses to external stimuli, which induce various inflammatory mediators from inflammatory cells, including innate lymphoid cells (ILCs) and T lymphocytes as well as epithelial cells. Thymic stromal lymphopoietin (TSLP), interleukin (IL)-25, and IL-33, which are mainly secreted by epithelial cells in response to external stimuli, act on type 2 ILCs and T helper 2 (Th2) cells, inducing IL-4, IL-5, and IL-13. Local immunoglobulin E (IgE) production is also a signature event in nasal polyps (NP). These inflammatory mediators are novel potential therapeutic targets for recalcitrant CRS. This article reviews recent publications regarding endotypes and endotype-based therapeut...Continue Reading

References

Nov 8, 2006·The Journal of Allergy and Clinical Immunology·Philippe GevaertClaus Bachert
Jan 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hai-Chon Lee, Steven F Ziegler
Jul 10, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Atsushi KatoRobert P Schleimer
Jan 23, 2008·Allergology International : Official Journal of the Japanese Society of Allergology·Shu HashimotoTomoko Kobayashi
Sep 23, 2008·The Journal of Allergy and Clinical Immunology·Nan ZhangClaus Bachert
Jun 9, 2009·The Journal of Allergy and Clinical Immunology·Nicholas Van BruaeneClaus Bachert
Jun 30, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hideaki KouzakiHirohito Kita
Apr 16, 2010·The Journal of Allergy and Clinical Immunology·Xiaoyuan LiClaus Bachert
Sep 3, 2010·The Journal of Allergy and Clinical Immunology·Claus BachertKristel Van Steen
Oct 7, 2010·The American Journal of the Medical Sciences·Tao LiuPing-Chang Yang
Nov 27, 2010·Thorax·María del Carmen VenneraManuel Bernal-Sprekelsen
Dec 15, 2010·Current Opinion in Allergy and Clinical Immunology·Nicholas Van Bruaene, Claus Bachert
Jun 30, 2011·American Journal of Rhinology & Allergy·Shino ShimizuTakeshi Shimizu
Oct 1, 2011·The Journal of Allergy and Clinical Immunology·Philippe GevaertClaus Bachert
Nov 19, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N Van BruaeneC Bachert
Nov 29, 2011·The Journal of Allergy and Clinical Immunology·Hye Young KimDale T Umetsu
Mar 31, 2012·The Journal of Allergy and Clinical Immunology·Weiping WenUNKNOWN Nasal Health Group, China (NHGC)
May 29, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Irina G LuzinaSergei P Atamas
Oct 2, 2012·The Journal of Allergy and Clinical Immunology·Philippe GevaertClaus Bachert
Oct 6, 2012·International Forum of Allergy & Rhinology·Matthew LamRichard J Harvey
Nov 17, 2012·American Journal of Respiratory and Critical Care Medicine·Tetsuji TakabayashiRobert P Schleimer
Mar 9, 2013·American Journal of Respiratory and Critical Care Medicine·Nicola A HananiaWilliam Busse
Apr 2, 2013·The Journal of Allergy and Clinical Immunology·Tetsuji TakabayashiRobert P Schleimer
May 22, 2013·The Journal of Allergy and Clinical Immunology·Deepti R NagarkarAtsushi Kato
Jun 29, 2013·American Journal of Respiratory and Critical Care Medicine·Joanne L ShawAmber Luong
Oct 15, 2013·The Laryngoscope·Shintaro BabaTatsuya Yamasoba
Jan 22, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nobuaki MizutaniShin Yoshino
Feb 15, 2014·World Journal of Clinical Cases·Elena LionettiMario La Rosa
May 23, 2014·The New England Journal of Medicine·Gail M GauvreauJane R Parnes
Jun 17, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S BabaT Yamasoba
Jul 10, 2014·The New England Journal of Medicine·Lisa A BeckAllen R Radin
Oct 22, 2014·International Forum of Allergy & Rhinology·Jacqueline HoRichard J Harvey
Nov 29, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Jacqueline HoRichard J Harvey
Dec 6, 2014·Current Opinion in Allergy and Clinical Immunology·Rohit Divekar, Hirohito Kita
Feb 24, 2015·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Tomohisa IinumaToshinori Nakayama
Mar 3, 2015·The Journal of Allergy and Clinical Immunology·Hyun-Woo ShinDae Woo Kim
Mar 3, 2015·Clinical and Experimental Otorhinolaryngology·Suk-Ho LeeKi-Sang Rha

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Citations

Mar 8, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y LiuZ Liu
Apr 21, 2018·American Journal of Rhinology & Allergy·Giuseppe BresciaGino Marioni
Oct 26, 2018·American Journal of Rhinology & Allergy·Nuray Bayar MulukGuy Scadding
Feb 23, 2019·Current Allergy and Asthma Reports·Ioannis VlastosEmmanuel P Prokopakis
Nov 8, 2018·Asia Pacific Allergy·Bernard Yu-Hor Thong
Mar 23, 2018·Allergo Journal International·Michael KoenneckeBarbara Wollenberg
Oct 1, 2019·Current Opinion in Allergy and Clinical Immunology·Gwanghui Ryu, Dae Woo Kim
Feb 14, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Gwanghui RyuDae Woo Kim
Mar 7, 2020·Allergy, Asthma & Immunology Research·Keisuke OrimoHideaki Morita
Jan 12, 2019·F1000Research·Eric F Succar, Justin H Turner
Feb 20, 2019·Frontiers in Immunology·Takechiyo YamadaHidekazu Saito
Mar 27, 2020·Journal of Translational Medicine·Emilie BequignonAndré Coste
Sep 5, 2020·International Forum of Allergy & Rhinology·Alyssa M CivantosNoam A Cohen
Sep 28, 2018·International Forum of Allergy & Rhinology·Neil N PatelNoam A Cohen
Jan 21, 2019·Allergy, Asthma & Immunology Research·Dong Kyu Kim, Dae Woo Kim
Aug 9, 2018·Allergy, Asthma & Immunology Research·Dong Kyu KimDae Woo Kim
Jan 21, 2019·Allergy, Asthma & Immunology Research·Dong Kyu KimDae Woo Kim
Jul 25, 2019·Allergy, Asthma & Immunology Research·Yi Sook KimHyun Woo Shin
Dec 7, 2018·Current Opinion in Otolaryngology & Head and Neck Surgery·Jonathan YipYvonne Chan
Feb 7, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Anju T PetersSiddhesh Kamat
Oct 17, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Tanya M LaidlawLeda P Mannent
Feb 20, 2021·Journal of Asthma and Allergy·Claus BachertAsif H Khan
Dec 25, 2019·Brazilian Journal of Otorhinolaryngology·Júlio Cláudio SousaMárcia Antoniazi Michelin
Jun 1, 2021·Frontiers in Molecular Biosciences·María Isabel Delgado-DolsetAlma Villaseñor
Nov 8, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Yanran HuangClaus Bachert

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BETA
biopsy

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