PMID: 19929816Nov 26, 2009Paper

Emerging evidence for neurotensin receptor 1 antagonists as novel pharmaceutics in neurodegenerative disorders

Mini Reviews in Medicinal Chemistry
Luca FerraroTiziana Antonelli

Abstract

The role that the tridecapeptide neurotensin (NT) plays in the modulation of the aminoacidergic transmission is analyzed in different rat brain regions. NT exerts its effects through the activation of different receptor subtypes, NTR1, NTR2 and NTR3. The contribution of NTR1 receptor in modulating and reinforcing glutamate signalling will be shown including the involvement of interactions between NT and N-methyl-D-aspartate (NMDA) receptors. Extracellular accumulation of glutamate and the excessive activation of glutamate receptors, in particular NMDA receptors, is known to represent an important factor in the induction of glutamate-mediated neuronal damage occurring in Parkinson's disease and in pathologic events such as hypoxia and ischemia. An enhancing action of NT on glutamate-induced neurodegenerative effects is shown and NTR1 receptor antagonists could therefore become novel pharmaceutics in the treatment of neurodegenerative disease.

Citations

Apr 18, 2013·Chemistry : a European Journal·Claudio BattilocchioSteven V Ley
Jan 13, 2016·Journal of Psychopharmacology·Luca FerraroMalgorzata Filip
Sep 6, 2019·Journal of Neurochemistry·Srinidhi JayaramanVardan T Karamyan
Mar 28, 2019·Frontiers in Neuroanatomy·Shu-Yin XuXiao-Xin Yan
May 3, 2019·Journal of Biomolecular Structure & Dynamics·Tristan RichardGrégory Da Costa
Aug 14, 2020·Neural Regeneration Research·Vardan T Karamyan

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