Emerging Evidences for an Implication of the Neurodegeneration-Associated Protein TAU in Cancer

Brain Sciences
Stéphanie Papin, Paolo Paganetti

Abstract

Neurodegenerative disorders and cancer may appear unrelated illnesses. Yet, epidemiologic studies indicate an inverse correlation between their respective incidences for specific cancers. Possibly explaining these findings, increasing evidence indicates that common molecular pathways are involved, often in opposite manner, in the pathogenesis of both disease families. Genetic mutations in the MAPT gene encoding for TAU protein cause an inherited form of frontotemporal dementia, a neurodegenerative disorder, but also increase the risk of developing cancer. Assigning TAU at the interface between cancer and neurodegenerative disorders, two major aging-linked disease families, offers a possible clue for the epidemiological observation inversely correlating these human illnesses. In addition, the expression level of TAU is recognized as a prognostic marker for cancer, as well as a modifier of cancer resistance to chemotherapy. Because of its microtubule-binding properties, TAU may interfere with the mechanism of action of taxanes, a class of chemotherapeutic drugs designed to stabilize the microtubule network and impair cell division. Indeed, a low TAU expression is associated to a better response to taxanes. Although TAU main bindi...Continue Reading

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Citations

Dec 11, 2020·Brain Sciences·Luca ColnaghiSarah Sertic
Jul 11, 2021·European Journal of Pharmacology·Bahareh ZarinGolnaz Vaseghi
Aug 18, 2021·The Protein Journal·Dan WangYongqi Huang

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Methods Mentioned

BETA
chromosomal aberration
transgenic
acetylation
ubiquitination
protein folding

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