Emerging functions for the Staphylococcus aureus RNome

PLoS Pathogens
Julien GuilletBrice Felden

Abstract

Staphylococcus aureus is a leading pathogen for animals and humans, not only being one of the most frequently isolated bacteria in hospital-associated infections but also causing diseases in the community. To coordinate the expression of its numerous virulence genes for growth and survival, S. aureus uses various signalling pathways that include two-component regulatory systems, transcription factors, and also around 250 regulatory RNAs. Biological roles have only been determined for a handful of these sRNAs, including cis, trans, and cis-trans acting RNAs, some internally encoding small, functional peptides and others possessing dual or multiple functions. Here we put forward an inventory of these fascinating sRNAs; the proteins involved in their activities; and those involved in stress response, metabolisms, and virulence.

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Citations

Feb 11, 2014·Nucleic Acids Research·Svetlana ChabelskayaBrice Felden
May 31, 2014·FEBS Letters·Pierre FechterPascale Romby
Oct 9, 2015·Journal of Medical Microbiology·Qing RaoXiancai Rao
Aug 5, 2015·Nucleic Acids Research·Hélène Le PabicBrice Felden
Apr 29, 2015·Frontiers in Microbiology·Saliha DurmuşReinhard Guthke
Aug 15, 2014·Frontiers in Cellular and Infection Microbiology·Richard A ProctorGeorg Peters
Nov 9, 2017·Microbial Genomics·Fabien J CousinPaul W O'Toole
Oct 28, 2019·Frontiers in Cellular and Infection Microbiology·Shubham Chakravarty, Eric Massé
Oct 28, 2017·Molecular Microbiology·Lauren M Sheehan, Clayton C Caswell
Apr 21, 2019·Microbiology Spectrum·E DesgrangesI Caldelari
Jun 24, 2016·Microbiology Spectrum·Sarah L Svensson, Cynthia M Sharma
Aug 10, 2021·Frontiers in Microbiology·Laura BarrientosIsabelle Caldelari
Oct 13, 2021·MSystems·Charlotte OriolAstrid Rouillon
Mar 26, 2015·RNA·Mohamed SassiBrice Felden

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Methods Mentioned

BETA
affinity purifications
environmental stresses

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