Emerging functions of multi-protein complex Mediator with special emphasis on plants

Critical Reviews in Biochemistry and Molecular Biology
Naveen MalikAkhilesh Tyagi

Abstract

Mediator is a multi-subunit protein complex which is involved in transcriptional regulation in yeast and other eukaryotes. As a co-activator, it connects information from transcriptional activators/repressors to transcriptional machinery including RNA polymerase II and general transcription factors. It is not only involved in transcription initiation but also has important roles to play in transcription elongation and termination. Functional attributes of different Mediator subunits have been largely defined in yeast and mammalian systems earlier, while such studies in plants have gained momentum recently. Mediator regulates various processes related to plant development and is also involved in biotic and abiotic stress response. Thus, plant Mediator, like yeast and mammalian Mediator complex, is indispensable for plant growth and survival. Interaction of its multiple subunits with other regulatory proteins and their ectopic expression or knockdown in model plant like Arabidopsis and certain crop plants are paving the way to biochemical analysis and unravel molecular mechanisms of action of Mediator in plants.

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Citations

Nov 9, 2019·The Plant Journal : for Cell and Molecular Biology·Naveen MalikAkhilesh K Tyagi
Feb 23, 2019·Nucleic Acids Research·Sourobh MajiJitendra K Thakur
Oct 28, 2019·International Journal of Molecular Sciences·Aneta Tarczewska, Beata Greb-Markiewicz
Apr 9, 2020·International Journal of Molecular Sciences·Vishnu Sukumari NathVipin Hallan
Oct 24, 2020·International Journal of Molecular Sciences·Leelyn ChongYingfang Zhu
Apr 20, 2021·Frontiers in Plant Science·Huijuan ZhangMing Jiang
Apr 4, 2021·The New Phytologist·Chan Man HaRichard A Dixon

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