Emerging importance of satellite glia in nervous system function and dysfunction.

Nature Reviews. Neuroscience
Menachem Hanani, David C Spray

Abstract

Satellite glial cells (SGCs) closely envelop cell bodies of neurons in sensory, sympathetic and parasympathetic ganglia. This unique organization is not found elsewhere in the nervous system. SGCs in sensory ganglia are activated by numerous types of nerve injury and inflammation. The activation includes upregulation of glial fibrillary acidic protein, stronger gap junction-mediated SGC-SGC and neuron-SGC coupling, increased sensitivity to ATP, downregulation of Kir4.1 potassium channels and increased cytokine synthesis and release. There is evidence that these changes in SGCs contribute to chronic pain by augmenting neuronal activity and that these changes are consistent in various rodent pain models and likely also in human pain. Therefore, understanding these changes and the resulting abnormal interactions of SGCs with sensory neurons could provide a mechanistic approach that might be exploited therapeutically in alleviation and prevention of pain. We describe how SGCs are altered in rodent models of four common types of pain: systemic inflammation (sickness behaviour), post-surgical pain, diabetic neuropathic pain and post-herpetic pain.

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Citations

Oct 22, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Liya Y Qiao, Namrata Tiwari
Feb 2, 2021·Neurochemical Research·Menachem Hanani, Alexei Verkhratsky
Dec 29, 2020·Frontiers in Cellular Neuroscience·Emily L Tran, LaTasha K Crawford
Feb 5, 2021·International Journal of Molecular Sciences·Jessica Aijia LiuChi Wai Cheung
Feb 26, 2021·Brain Research·Rachel Feldman-Goriachnik, Menachem Hanani
May 4, 2021·British Journal of Pharmacology·Hannes SchmidtAchim Schmidtko
Jun 17, 2021·Journal of Anatomy·Chelsey B ReedEmma R Wilson
May 26, 2021·The Journal of Physiology·Menachem Hanani, Robert W Banks
Jul 2, 2021·The Journal of Clinical Investigation·Kevin J Tracey
Aug 5, 2021·Anesthesia and Analgesia·Mouna Ben RehoumaJean Xavier Mazoit
Aug 18, 2021·Clinical Rheumatology·Manuel Martínez-Lavín
Aug 28, 2021·Biomedicines·Kjeld Morten MohrChristian Bjerggaard Vaegter
Aug 24, 2021·The Journal of Pain : Official Journal of the American Pain Society·Robert D GrahamScott F Lempka
Aug 27, 2021·Frontiers in Neuroendocrinology·Haiyan ZhengSun Wook Hwang
Sep 2, 2021·Developmental Cell·Ozge E Tasdemir-YilmazRosalind A Segal
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Sep 18, 2021·Journal of Neuroinflammation·Becky J ProskocilMatthew G Drake
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Oct 3, 2021·Nature Reviews. Neuroscience·Emily Scott-SolomonRejji Kuruvilla
Nov 11, 2021·Science Translational Medicine·Selwyn JayakarClifford J Woolf
Nov 19, 2021·Purinergic Signalling·Manuel F MuñozJorge E Contreras

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Methods Mentioned

BETA
electron microscopy

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