Emerging Loop-Mediated Isothermal Amplification-Based Microchip and Microdevice Technologies for Nucleic Acid Detection

ACS Biomaterials Science & Engineering
Mohammadali SafaviehHadi Shafiee

Abstract

Rapid, sensitive, and selective pathogen detection is of paramount importance in infectious disease diagnosis and treatment monitoring. Currently available diagnostic assays based on polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA) are time-consuming, complex, and relatively expensive, thus limiting their utility in resource-limited settings. Loop-mediated isothermal amplification (LAMP) technique has been used extensively in the development of rapid and sensitive diagnostic assays for pathogen detection and nucleic acid analysis and hold great promise for revolutionizing point-of-care molecular diagnostics. Here, we review novel LAMP-based lab-on-a-chip (LOC) diagnostic assays developed for pathogen detection over the past several years. We review various LOC platforms based on their design strategies for pathogen detection and discuss LAMP-based platforms still in development and already in the commercial pipeline. This review is intended as a guide to the use of LAMP techniques in LOC platforms for molecular diagnostics and genomic amplifications.

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Citations

Aug 24, 2017·Lab on a Chip·Catherine E MajorsRebecca Richards-Kortum
Jan 9, 2019·Analytical and Bioanalytical Chemistry·Roland MartzyGeorg H Reischer
Apr 3, 2019·Annual Review of Analytical Chemistry·Dong Jin ShinTza-Huei Wang
Jun 30, 2019·Micromachines·Lena GorgannezhadNam-Trung Nguyen
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Jan 22, 2019·Journal of Medical Devices·Carlos A HerradaWaseem Asghar
Apr 20, 2016·Critical Reviews in Biotechnology·Mohammadali SafaviehWaseem Asghar
Feb 10, 2021·Medicinal Research Reviews·Xianlong ZhangTony D James
Feb 15, 2017·Analytical Chemistry·Dohwan LeeJeong Hoon Lee
Mar 16, 2017·ACS Applied Materials & Interfaces·Mohammadali SafaviehHadi Shafiee
May 14, 2019·ACS Omega·Waseem AsgharUtkan Demirci
Nov 10, 2018·Analytical Chemistry·Yanling SongChaoyong Yang
Dec 21, 2017·Analytical Chemistry·Jiayun HuPaul W Bohn
Sep 26, 2020·ACS Sensors·Thierry LeïchléThomas Alava

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