Emerging modes of collective cell migration induced by geometrical constraints

Proceedings of the National Academy of Sciences of the United States of America
Sri Ram Krishna VedulaBenoît Ladoux


The role of geometrical confinement on collective cell migration has been recognized but has not been elucidated yet. Here, we show that the geometrical properties of the environment regulate the formation of collective cell migration patterns through cell-cell interactions. Using microfabrication techniques to allow epithelial cell sheets to migrate into strips whose width was varied from one up to several cell diameters, we identified the modes of collective migration in response to geometrical constraints. We observed that a decrease in the width of the strips is accompanied by an overall increase in the speed of the migrating cell sheet. Moreover, large-scale vortices over tens of cell lengths appeared in the wide strips whereas a contraction-elongation type of motion is observed in the narrow strips. Velocity fields and traction force signatures within the cellular population revealed migration modes with alternative pulling and/or pushing mechanisms that depend on extrinsic constraints. Force transmission through intercellular contacts plays a key role in this process because the disruption of cell-cell junctions abolishes directed collective migration and passive cell-cell adhesions tend to move the cells uniformly toget...Continue Reading


Mar 16, 2004·Cell·Grégory GiannoneMichael P Sheetz
Dec 15, 2004·Biophysical Journal·Hisashi HagaKazushige Kawabata
Feb 8, 2005·Proceedings of the National Academy of Sciences of the United States of America·Olivia du RoureBenoît Ladoux
Feb 16, 2006·The International Journal of Developmental Biology·D E Ingber
Feb 24, 2006·American Journal of Physiology. Cell Physiology·Djordje L NikolićStanislav Y Shvartsman
Feb 7, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·B SzabóTamás Vicsek
Oct 2, 2007·Proceedings of the National Academy of Sciences of the United States of America·M PoujadeP Silberzan
May 24, 2008·Nature·Kinneret KerenJulie A Theriot
Jun 4, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Hugues ChatéFranck Raynaud
Feb 18, 2009·The Journal of Cell Biology·Andrew D DoyleKenneth M Yamada
Jun 24, 2009·Nature Reviews. Molecular Cell Biology·Peter Friedl, Darren Gilmour
Sep 4, 2009·Journal of Cell Science·Cornelis J Weijer
Sep 10, 2009·Cancer Research·Takanori TsujiGuo-fu Hu
Sep 26, 2009·Developmental Biology·Deborah J Andrew, Andrew J Ewald
Feb 2, 2010·HFSP Journal·Nir Gov
Feb 10, 2010·Biophysical Journal·Shirley MarkP Silberzan
Apr 2, 2010·Journal of the Royal Society, Interface·Jin-Hong KimAnand R Asthagiri
Apr 9, 2010·Nature·Máté NagyTamás Vicsek
Apr 21, 2010·The Journal of Cell Biology·Jacqueline M BenjaminW James Nelson
Apr 22, 2010·Experimental Cell Research·James I LimGaudenz Danuser
May 6, 2010·Biophysical Journal·L PetitjeanP Silberzan
May 21, 2010·Physical Review Letters·Thomas E AngeliniDavid A Weitz
Jun 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·Nicolas BorghiW James Nelson
Sep 3, 2010·Nature·Volker SchallerA R Bausch
Oct 5, 2010·Integrative Biology : Quantitative Biosciences From Nano to Macro·Antoine A Khalil, Peter Friedl
Feb 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Thomas E AngeliniDavid A Weitz
Mar 10, 2011·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Alexandre SaezBenoît Ladoux
May 24, 2011·Nature Materials·Dhananjay T TambeXavier Trepat
Jul 30, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Pilhwa Lee, Charles Wolgemuth


Dec 10, 2013·Biomaterials·Marine VerhulselJean-Louis Viovy
Jun 21, 2013·Integrative Biology : Quantitative Biosciences From Nano to Macro·Kevin DoxzenChwee Teck Lim
Apr 26, 2013·Lab on a Chip·Aoi OdawaraIkuro Suzuki
Jul 27, 2012·Journal of the Royal Society, Interface·Alexandre J Kabla
Sep 21, 2013·Journal of the Royal Society, Interface·Ravi A DesaiChristopher S Chen
Mar 13, 2014·Nature Materials·Daniel J CohenMichel M Maharbiz
Oct 24, 2013·Biomedical Microdevices·Tina Qing HuangShaochen Chen
Mar 25, 2014·Mathematical Biosciences·Abderrahmane HabbalGrégoire Malandain
May 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Grégory BeauneFrançoise Brochard-Wyart
May 17, 2014·Cell Death and Differentiation·J K LiuJ N Rich
Sep 1, 2014·Nature Physics·Agustí BruguésXavier Trepat
Feb 4, 2016·Cell Adhesion & Migration·Philipp J Albert, Ulrich S Schwarz
Feb 19, 2014·Current Opinion in Chemical Biology·Jens VoskuhlPascal Jonkheijm
Jul 17, 2013·Current Opinion in Biotechnology·Katarina BlagovicAnand R Asthagiri
Jan 22, 2015·Biophysical Journal·Steven M ZehnderThomas E Angelini
Jan 10, 2016·Journal of Biomechanics·Nicholas A KurniawanChwee Teck Lim
Oct 9, 2014·Biophysical Journal·Bo Li, Sean X Sun
Nov 2, 2015·Trends in Cell Biology·Brenton D Hoffman, Alpha S Yap
Feb 28, 2016·Trends in Cell Biology·Benoît LadouxXavier Trepat
Dec 9, 2014·Cell Adhesion & Migration·James E N JonkmanPina Colarusso
Nov 11, 2015·The Journal of Cell Biology·Charlotte Guetta-TerrierNils C Gauthier
Jun 2, 2015·Biochimica Et Biophysica Acta·Matthias ZornJoachim O Rädler
Jul 22, 2015·The Journal of Cell Biology·Pierre-Olivier StraleRené-Marc Mège
Apr 30, 2015·Proceedings of the National Academy of Sciences of the United States of America·Hannah G YevickP Silberzan
Sep 5, 2014·Biophysical Journal·Anna-Kristina MarelJoachim O Rädler
Apr 14, 2016·Biophysical Journal·Vincent NierPhilippe Marcq
Feb 26, 2016·Molecular Biology of the Cell·Pascale MonzoMichael P Sheetz
Jul 4, 2015·Trends in Cell Biology·Anna HaegerPeter Friedl
Jun 2, 2015·Frontiers in Bioengineering and Biotechnology·Kristin HauffElisabetta Ada Cavalcanti-Adam
Dec 23, 2015·Cellular and Molecular Bioengineering·Mark L Lalli, Anand R Asthagiri
Jan 23, 2014·Proceedings of the National Academy of Sciences of the United States of America·Camila LondonoAlison P McGuigan
Jun 12, 2013·Communicative & Integrative Biology·Man Chun LeongBenoît Ladoux
Jul 6, 2014·Current Opinion in Cell Biology·Sandrine Etienne-Manneville
May 3, 2014·Journal of Theoretical Biology·Katrina K TreloarRuth E Baker
Apr 27, 2016·The Journal of Cell Biology·Wangsun ChoiMark Peifer
May 1, 2016·Current Opinion in Cell Biology·Simon BegnaudBenoît Ladoux
Jun 1, 2016·The Journal of Cell Biology·András SzabóRoberto Mayor
Jun 1, 2016·Scientific Reports·Christoph SchreiberJoachim O Rädler
Oct 21, 2014·PloS One·Annika KastenRolf E Brenner
Feb 7, 2013·BioTechniques·Benjamin SlaterAlison P McGuigan
Jul 16, 2016·Annual Review of Biomedical Engineering·Colin D PaulKonstantinos Konstantopoulos
Jul 28, 2016·Scientific Reports·Ki-Hwan NamDeok-Ho Kim
Oct 18, 2016·Current Biology : CB·Leyla KocgozluBenoît Ladoux
Dec 2, 2016·Nature Reviews. Cancer·Colin D PaulKonstantinos Konstantopoulos
Dec 23, 2016·Cellular and Molecular Life Sciences : CMLS·Bryan A NergerCeleste M Nelson
Jan 14, 2017·Molecular Oncology·Pahini PandyaVictoria Sanz-Moreno
Mar 18, 2015·Scientific Reports·Jakob LöberIgor S Aranson
Jan 27, 2017·Molecular Biology of the Cell·Nishit SrivastavaAlexandre J Kabla
Feb 24, 2017·Molecular Biology of the Cell·G R Ramirez-San JuanM L Gardel
Apr 14, 2017·Nature·Thuan Beng SawBenoît Ladoux
May 17, 2017·Nature Communications·Amin DoostmohammadiJulia M Yeomans
Mar 28, 2017·Soft Matter·Tyler N ShendrukJulia M Yeomans
Mar 14, 2014·Soft Matter·José AlvaradoGijsje H Koenderink
Dec 21, 2016·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Jun Nakanishi
Mar 30, 2017·Lab on a Chip·James CheDino Di Carlo
May 12, 2015·Physical Chemistry Chemical Physics : PCCP·Masao KamimuraJun Nakanishi
Sep 25, 2015·Integrative Biology : Quantitative Biosciences From Nano to Macro·Andrea RavasioBenoît Ladoux
Apr 30, 2015·Integrative Biology : Quantitative Biosciences From Nano to Macro·Kathryn E WorleyLeo Q Wan
Jan 23, 2016·Soft Matter·Pierre RechoPhilippe Marcq
Jul 25, 2014·Integrative Biology : Quantitative Biosciences From Nano to Macro·Előd Méhes, Tamás Vicsek
Jun 20, 2017·Development, Growth & Differentiation·Koichiro Uriu, Luis G Morelli
Mar 2, 2018·PLoS Computational Biology·Yohei KondoShin Ishii
Oct 5, 2017·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Carl-Magnus SvenssonMarc Thilo Figge
Aug 22, 2017·Soft Matter·C Blanch-Mercader, J Casademunt
Nov 17, 2017·Nature Communications·Wang XiChwee Teck Lim
Oct 16, 2016·Integrative Biology : Quantitative Biosciences From Nano to Macro·Mariia LunovaAlexandr Dejneka
Mar 11, 2017·Reports on Progress in Physics·Vincent Hakim, P Silberzan
May 4, 2017·Physical Biology·Victoria TarleNir Gov
Nov 9, 2017·Nature Reviews. Molecular Cell Biology·Benoît Ladoux, René-Marc Mège
Dec 8, 2017·Scientific Reports·Tamara AdvedissianFrédérique Deshayes
Dec 3, 2013·Nature Materials·Sri Ram Krishna VedulaBenoît Ladoux
Jun 13, 2017·Experimental Dermatology·Nathalie DeshayesMaryline Paris
Jun 9, 2018·Advanced Materials·Pingqiang CaiXiaodong Chen
Apr 14, 2016·Journal of Cell Science·Aneesh R SatheMichael P Sheetz
Sep 26, 2017·Connective Tissue Research·Gyudo LeeJeffrey J Fredberg
Aug 30, 2018·Advanced Materials·Thuan Beng SawChwee Teck Lim
Jul 16, 2016·Science Advances·Sumesh P ThampiJulia M Yeomans
Feb 4, 2016·Nature Communications·Amin DoostmohammadiJulia M Yeomans
Nov 27, 2018·Annual Review of Genetics·András Szabó, Roberto Mayor
Mar 30, 2019·Proceedings of the National Academy of Sciences of the United States of America·Jian ZhangCynthia A Reinhart-King
Jul 11, 2015·Nature Communications·Andrea RavasioBenoît Ladoux
Sep 8, 2017·Royal Society Open Science·Adrien HallouAlexandre J Kabla
Aug 1, 2019·Journal of the Royal Society, Interface·Shao-Zhen LinXi-Qiao Feng
Aug 28, 2019·Soft Matter·Felix KempfAmin Doostmohammadi
Oct 8, 2019·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Shota YamamotoJun Nakanishi
Nov 21, 2017·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Shaoliang LuanJian Chen
Mar 7, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Frédéric H LoginLene N Nejsum
Jun 4, 2020·Soft Matter·Linda RavazzanoStefano Zapperi
Jun 3, 2020·Biotechnology and Bioengineering·Laura AlaimoSylvain Gabriele
Jul 2, 2020·Current Protocols in Cell Biology·Jean-Loup DubandSylvie Dufour
May 31, 2019·Integrative Biology : Quantitative Biosciences From Nano to Macro·Benjamin SlaterAlison P McGuigan
Sep 24, 2020·The Journal of Cell Biology·Shafali Gupta, Alpha S Yap
Aug 6, 2016·Physical Review Letters·Amin DoostmohammadiJulia M Yeomans
May 12, 2017·Journal of the Royal Society, Interface·Rachel M LeeWolfgang Losert
Aug 8, 2018·Scientific Reports·Jakia Jannat KeyaAkira Kakugo
Dec 16, 2018·Bioengineering·Kazusa BeppuRyota Sakamoto
Jan 5, 2019·Journal of Cell Science·Jiahui Cao, Hans Schnittler
Apr 17, 2019·Journal of Cell Science·Adam Shellard, Roberto Mayor
Aug 8, 2020·Advanced Healthcare Materials·Min BaoWilhelm T S Huck
Sep 11, 2020·Physical Review Letters·S TliliH Delanoë-Ayari
Jun 25, 2015·Soft Matter·Nick GravishDaniel I Goldman
Nov 14, 2015·Physical Review Letters·Katsuhiko SatoTatsuo Shibata
Aug 30, 2017·Soft Matter·Shunsuke Yabunaka, Philippe Marcq
Jun 5, 2018·Physical Review Letters·C Blanch-MercaderP Silberzan
Aug 22, 2018·Advanced Science·Min BaoWilhelm T S Huck
Jun 27, 2019·Journal of Biochemistry·Takanori TakahashiYukio Fujiki
Jun 14, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wenqiang DuJiaru Chu
Nov 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Young Min ShinHeung Jae Chun
Jan 18, 2017·Cold Spring Harbor Perspectives in Biology·René Marc Mège, Noboru Ishiyama
Jul 8, 2017·Molecular Biology of the Cell·Chiara De Pascalis, Sandrine Etienne-Manneville
Oct 11, 2016·Soft Matter·Marielena Gamboa CastroIan Y Wong
Feb 13, 2018·Applied Physics Letters·Fan XiaoPei-Yu Chiou
Dec 23, 2018·Journal of Cell Science·Tianchi ChenBenoît Ladoux
Jul 23, 2019·F1000Research·Willem-Jan PannekoekMartijn Gloerich
Oct 24, 2019·Physical Review. E·Dietmar OelzZoltan Neufeld
Jan 31, 2020·Biomechanics and Modeling in Mechanobiology·Tyler A CollinsParag Katira
May 20, 2020·Scientific Reports·Hamid KhataeeZoltan Neufeld
Jul 28, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Adam Shellard, Roberto Mayor
Dec 27, 2015·Physical Review Letters·Romaric VincentXavier Trepat
Jun 13, 2018·Royal Society Open Science·Sham TliliFrançois Graner
Apr 13, 2018·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Brian A Camley
Dec 12, 2018·Médecine sciences : M/S·René Marc Mège, Benoît Ladoux
Oct 5, 2019·Integrative Biology : Quantitative Biosciences From Nano to Macro·Yugo TabataKenichi Funamoto
Jul 28, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Medhavi VishwakarmaTamal Das
Nov 5, 2013·Physiology·Sri Ram Krishna VedulaBenoît Ladoux
Sep 28, 2017·Physical Review. E·Shunsuke Yabunaka, Philippe Marcq
Apr 15, 2016·Physical Review. E·E J HemingwayS M Fielding
Apr 22, 2014·Physical Review Letters·Gary WilkBartosz A Grzybowski
Nov 11, 2020·Biology of the Cell·Hiroko Katsuno-KambeJessica L Teo
Dec 11, 2020·PLoS Computational Biology·Andreas Buttenschön, Leah Edelstein-Keshet
Nov 13, 2020·Advanced Biosystems·Shao-Zhen LinXi-Qiao Feng
Oct 21, 2020·Translational Oncology·Jia-Shun WuXin-Hua Liang
Mar 5, 2021·Scientific Reports·Deekshitha JettaSusan Z Hua
Nov 8, 2017·Developmental Cell·Kazuhiro AokiMichiyuki Matsuda
Aug 21, 2019·Seminars in Cell & Developmental Biology·Rachel M Lee, Wolfgang Losert
Mar 16, 2021·Frontiers in Oncology·Maria Paz Hernández-CáceresCristina Bertocchi
Jul 19, 2013·Biology Open·Tsuyoshi HirashimaMasaharu Nagayama
Nov 23, 2019·Current Opinion in Cell Biology·Lavinia CapuanaSandrine Etienne-Manneville
May 3, 2021·Journal of Theoretical Biology·D PramanikR Bhat

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Ester AnonBenoît Ladoux
Integrative Biology : Quantitative Biosciences From Nano to Macro
Kevin DoxzenChwee Teck Lim
Proceedings of the National Academy of Sciences of the United States of America
M PoujadeP Silberzan
© 2021 Meta ULC. All rights reserved