Emerging molecular biomarker targets for amyotrophic lateral sclerosis

Clinica Chimica Acta; International Journal of Clinical Chemistry
Julia Costa, Mamede de Carvalho

Abstract

Amyotrophic lateral sclerosis is a rapidly progressive neurodegenerative disease that affects upper (UMN) and lower motor (LMN) neurons. It is associated with a short survival and there is no effective treatment, in spite of a large number of clinical trials. Strong efforts have been made to identify novel disease biomarkers to support diagnosis, provide information on prognosis, to measure disease progression in trials and increase our knowledge on disease pathogenesis. Electromyography by testing the function of the LMN can be used as a biomarker of its dysfunction. A number of electrophysiological and neuroimaging methods have been explored to identify a reliable marker of UMN degeneration. Recently, strong evidence from independent groups, large cohorts of patients and multicenter studies indicate that neurofilaments are very promising diagnostic biomarkers, in particular cerebrospinal fluid and blood levels of phosphoneurofilament heavy chain and neurofilament light chain. Furthermore, their increased levels are associated with poor prognosis. Additional studies have been performed aiming to identify other biomarkers, which alone or in combination with neurofilaments could increase the sensitivity and the specificity of th...Continue Reading

References

Jan 1, 1988·Journal of Neuropathology and Experimental Neurology·D G MunozD J Selkoe
Aug 1, 1996·Journal of the Neurological Sciences·M de CarvalhoM L Luís
Jan 27, 1998·Neurology·N StamblerJ M Cedarbaum
Oct 4, 2000·JAMA : the Journal of the American Medical Association·B A HoslerR H Brown
Nov 14, 2001·American Journal of Human Genetics·Collette K HandGuy A Rouleau
Nov 2, 2002·Neuroepidemiology·Ettore BeghiUNKNOWN Italian ALS Study Group
Feb 26, 2003·Neurology·Jessica MandrioliPatrizia Sola
Apr 24, 2004·American Journal of Human Genetics·Ying-Zhang ChenPhillip F Chance
Nov 30, 2005·Muscle & Nerve·Steve VucicMatthew C Kiernan
Dec 16, 2005·Redox Report : Communications in Free Radical Research·Aleksandra Nikolić KokićMihajlo B Spasić
Feb 17, 2006·Neurology·G M PasinettiL Ho
Feb 28, 2006·Nature Genetics·Matthew J GreenwayOrla Hardiman
Mar 29, 2006·Neurology·J BrettschneiderH Tumani
Jun 30, 2006·Neurology·N ParkinsonUNKNOWN FReJA Consortium
Sep 14, 2007·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Liliana Olim Gouveia, Mamede de Carvalho
Oct 2, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H ZetterbergP M Andersen
Jan 1, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mamede de CarvalhoMichael Swash
Mar 1, 2008·Science·Jemeen SreedharanChristopher E Shaw
Jun 25, 2008·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Katrin FrutigerTeepu Siddique
Nov 8, 2008·Acta Neuropathologica·Takashi KasaiMasanori Nakagawa
Dec 17, 2008·Lancet Neurology·Martin R TurnerKevin Talbot
Mar 20, 2009·Journal of Neurology·Thierry S ReijnMarcel M Verbeek
Oct 27, 2009·Neuroscience Letters·Johannes BrettschneiderHayrettin Tumani
Jan 30, 2010·Brain : a Journal of Neurology·Antonio OrlacchioToshitaka Kawarai
Apr 20, 2010·Journal of Molecular Biology·Christian Münch, Anne Bertolotti
Oct 15, 2010·CNS & Neurological Disorders Drug Targets·Júlia CostaMamede de Carvalho
Dec 4, 2010·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Yu-Ichi NotoSatoshi Kuwabara
Dec 15, 2010·Neuron·Janel O JohnsonBryan J Traynor
Jan 14, 2011·Journal of Neurochemistry·Per ZetterströmStefan L Marklund
Mar 23, 2011·Journal of Neurochemistry·Jeban GanesalingamRobert Bowser
Jul 5, 2011·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Rita CarilhoJúlia Costa
Aug 16, 2011·Annals of Neurology·Amr Al-SaifSaeed Bohlega
Sep 15, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies· Markus Weber
Nov 26, 2011·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Kay A LawtonJames D Berry
Jan 5, 2012·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Markus OttoUNKNOWN Volcano Group

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Citations

Apr 22, 2016·Journal of Neural Transmission·Kurt A Jellinger, Gregor K Wenning
Jul 2, 2016·Neurophysiologie clinique = Clinical neurophysiology·Jean-Pascal Lefaucheur, Mamede de Carvalho
Aug 20, 2016·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Margarida GonçalvesJúlia Costa
Jan 27, 2017·BMC Neuroscience·Stephanie M WilliamsMichael R Sierks
Nov 22, 2017·PloS One·Laura ColombaioniEmilia Bramanti
Jan 23, 2018·Omics : a Journal of Integrative Biology·Konstantinos MitropoulosGeorgios Pampalakis
Dec 18, 2018·Human Mutation·Georgios PampalakisGeorge P Patrinos
Nov 9, 2019·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Karen R GarnaasMikki Behnke
Jan 11, 2019·Disease Models & Mechanisms·Francesca De GiorgioAbraham Acevedo-Arozena
Jun 15, 2019·International Journal of Molecular Sciences·Laura Moreno-MartinezRosario Osta
May 29, 2018·The Journal of International Medical Research·Simona PortaroRocco Salvatore Calabrò
Apr 26, 2019·Frontiers in Neurology·Jose-Luis González De Aguilar
May 28, 2020·International Journal of Molecular Sciences·Roberta BonafedeRaffaella Mariotti
Apr 6, 2017·Frontiers in Cellular Neuroscience·Roberta Bonafede, Raffaella Mariotti

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