Emerging Nano Drug Delivery Systems Targeting Cancer-Associated Fibroblasts for Improved Antitumor Effect and Tumor Drug Penetration.

Molecular Pharmaceutics
Jian GuoYan Chen

Abstract

Currently, clinically used antitumor nanomedicine is usually insufficient to eradicate malignancies, due to the tumor stroma exerting therapeutic resistance and physical barriers for proper drug delivery. As the most abundant cells in the tumor stroma, cancer-associated fibroblasts (CAFs) produce a critical tumor-promoting effect and barriers preventing the physical delivery of nanomedicines through secreting pro-tumorigenic cytokines, increasing solid tumor pressure and interstitial fluid pressure (IFP), and nonspecific internalization. Therefore, beyond treatment centered on cancer cells, researchers are focusing on targeting CAFs to fight stromal-rich tumors. In recent years, a series of novel nano delivery systems have been developed based on specific CAF-targeted ligands and advanced biofunctional materials. On the one hand, CAF-targeted nano delivery systems inhibit the pro-tumor signaling pathway between CAFs and cancer cells to reverse tumorigenesis, immunosuppression, or drug resistance in the tumor microenvironment, thus improving the sensitivity to antitumor treatments. On the other hand, nanostrategies acting on CAFs profoundly contribute to increasing the deep penetration of antitumor drugs through the decrease of ...Continue Reading

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Citations

Jul 2, 2020·International Journal of Molecular Sciences·Edward SuhendraYi-Chin Hsieh
Dec 12, 2020·Acta Pharmaceutica Sinica. B·Yuefei ZhuZhiqing Pang
Jan 23, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·David VetvickaDavid Oupický
Apr 23, 2021·Biochemical Pharmacology·Soumeya AbedAnthony F Rullo
May 16, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Chen YunnaChen Weidong
Jun 24, 2021·Advanced Healthcare Materials·Yong-Jiang LiDa-Xiong Xiang

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