Emerging new drugs for scar reduction

Expert Opinion on Emerging Drugs
Karen Meier, Lillian B Nanney

Abstract

Hypertropic and keloid scars cause both functional and cosmetic problems for those afflicted. Although people of all ages suffer from these conditions, the patients are often young and otherwise healthy, and become burdened with an activity limiting lesion or psychosocial stresses associated with a perceived aesthetic defect. Currently available treatment modalities are often inconvenient, occasionally painful, and have unwanted side effects. Despite the highest standard of care, treatment protocols are prone to failure with high rates of scar recurrence. Hypertropic and keloid scars are the result of an abnormal healing response and may result from an extended inflammatory phase in the wound healing process. Regardless of the causes, which remain elusive, excessive collagen deposition occurs relative to normal wounds. This extracellular matrix collagen accumulation makes a logical target for pharmacological interventions, and researchers are attempting to modify collagen-synthetic and -degradative pathways. In addition, growth factors and cytokines have been implicated in scar formation, and these factors are targeted for potential therapeutic use in scar management. Cytotoxic agents are also being evaluated for their potentia...Continue Reading

References

Sep 1, 1976·AJR. American Journal of Roentgenology·D S LevyR E Roth
Nov 1, 1992·British Journal of Plastic Surgery·Y Sawada, K Sone
Jul 1, 1992·British Journal of Plastic Surgery·Y W Tang
Apr 1, 1991·Archives of Surgery·S T AhnT A Mustoe
Jan 1, 1990·British Journal of Plastic Surgery·D D Datubo-Brown
Jan 1, 1990·British Journal of Plastic Surgery·I F Muir
Nov 1, 1989·Plastic and Reconstructive Surgery·W B RockwellH P Ehrlich
Jan 1, 1989·British Journal of Plastic Surgery·N S Mercer
Oct 1, 1987·Burns, Including Thermal Injury·K J Quinn
Jan 1, 1986·Lasers in Surgery and Medicine·J P Hulsbergen HenningM J van Gemert
Feb 1, 1974·Plastic and Reconstructive Surgery·L D KetchumF W Masters
Mar 1, 1974·Plastic and Reconstructive Surgery·K M RamakrishnanC R Sundararajan
Dec 1, 1969·Plastic and Reconstructive Surgery·S M Alhady, K Sivanantharajah
Dec 1, 1982·Plastic and Reconstructive Surgery·J P Shepherd, R P Dawber
Jan 1, 1982·Aesthetic Plastic Surgery·B HirshowitzA R Moscona
Jul 1, 1995·Journal of the American Academy of Dermatology·B Berman, H C Bieley
Nov 10, 1994·The New England Journal of Medicine·W A Border, N A Noble
Mar 1, 1994·The Journal of Burn Care & Rehabilitation·J JohnsonC Goodwin
Jun 1, 1993·The Journal of Dermatologic Surgery and Oncology·L RuscianiR Bono
Jan 1, 1996·Plastic and Reconstructive Surgery·K N DolynchukJ M Serletti
Sep 1, 1995·The Journal of Burn Care & Rehabilitation·P ChangG P Kealey
Dec 1, 1995·The Journal of Surgical Research·C C ChangS H Jee
Oct 1, 1996·Annals of Plastic Surgery·N I Cruz-Korchin
Jun 1, 1997·The Surgical Clinics of North America·E E TredgetA Ghahary
Mar 12, 1998·Molecular Medicine Today·T L Tuan, L S Nichter
May 26, 1998·Annals of Plastic Surgery·D ChauM T Longaker
Nov 12, 1998·Plastic and Reconstructive Surgery·T S Alster, C A Nanni
Nov 24, 1998·Biochimica Et Biophysica Acta·H JuI M Dixon
Dec 16, 1998·British Journal of Plastic Surgery·D HuG W Cherry
Apr 8, 1999·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·R E Fitzpatrick
Oct 8, 1999·Plastic and Reconstructive Surgery·F B NiessenM Kon
Mar 14, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·E E TredgetA Ghahary
Feb 15, 2001·Plastic and Reconstructive Surgery·W G Lyle, UNKNOWN Plastic Surgery Educational Foundation DATA Committee
Nov 8, 2001·Plastic and Reconstructive Surgery·V K Rumalla, G L Borah
Jan 25, 2002·Journal of the American Academy of Dermatology·Joseph J ShafferFran Cook-Bolden
Apr 25, 2003·Plastic and Reconstructive Surgery·Yaron Har-ShaiEdmond Sabo
Jun 26, 2003·The Surgical Clinics of North America·Martin C Robson
Sep 3, 2003·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Filippo RenòMario Cannas
Sep 3, 2003·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Injoong KimThomas A Mustoe

❮ Previous
Next ❯

Citations

May 5, 2010·Plastic and Reconstructive Surgery·Benjamin C BrownArdeshir Bayat
Oct 1, 2013·Plastic and Reconstructive Surgery·Giorgio MancaFrancesca de Terlizzi
Jul 18, 2012·Proceedings of the American Thoracic Society·Boris Hinz
Jul 17, 2009·Expert Opinion on Investigational Drugs·Nick L OcclestonMark W J Ferguson
Mar 22, 2014·Journal of Pharmaceutical Sciences·Prashanth MandaS Narasimha Murthy
Jul 16, 2010·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·D C G SainsburyT Muir
Oct 1, 2008·Drug Discovery Today·Nick L OcclestonMark W J Ferguson
Sep 3, 2010·Dermatology Research and Practice·Jim BushMark W J Ferguson
Aug 21, 2010·Journal of Biomedical Materials Research. Part a·Emily C LynamZee Upton
Aug 4, 2011·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Nick L OcclestonMark W J Ferguson
May 15, 2012·Journal of Biomedical Materials Research. Part a·Brooke L FarrugiaTim R Dargaville
Aug 30, 2008·The American Journal of Pathology·Lillian B NanneyLeslie I Gold
Dec 16, 2011·Current Biology : CB·Lara BuscemiBoris Hinz
Mar 19, 2016·Advances in Wound Care·Lloyd F Rose, Rodney K Chan
Sep 2, 2008·The International Journal of Lower Extremity Wounds·Piyush DuraniMark W J Ferguson
Nov 20, 2016·The Journal of Investigative Dermatology·Christina L GrekGautam S Ghatnekar
Mar 31, 2011·The Journal of Hand Surgery, European Volume·S K Tolerton, M A Tonkin
Feb 9, 2018·Organogenesis·Michael S HuMichael T Longaker
Jul 25, 2008·The Journal of Craniofacial Surgery·Brian BermanIsaac S Jones
Aug 28, 2020·Frontiers in Physiology·Sun Hyung KwonGeoffrey C Gurtner
Mar 2, 2017·Tissue Engineering and Regenerative Medicine·Ji-Young YoonJi-Uk Yoon
May 21, 2021·Frontiers in Bioengineering and Biotechnology·Dharshan SivarajGeoffrey C Gurtner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.