Emerging opportunities for site-specific molecular and cellular interventions in autoimmune hepatitis.

Digestive Diseases and Sciences
A J Czaja

Abstract

Current corticosteroid-based treatments of autoimmune hepatitis frequently have incomplete or unsatisfactory outcomes, side effects, and excessive immune suppression. The goal of this review is to describe the advances in developing animal models of autoimmune hepatitis and in treating diverse immune-mediated diseases that make pursuit of site-specific molecular and cellular inventions in autoimmune hepatitis feasible. Prime source and review articles in English were selected by a Medline search through October 2009. A murine model infected with an adenovirus expressing human CYP2D6 is a resource for evaluating new therapies because of its histological and serological features, persistence, and progressive hepatic fibrosis. Synthetic analog peptides that block autoantigen expression, a dimeric recombinant human fusion protein of cytotoxic T lymphocyte antigen-4, monoclonal antibodies against tumor necrosis factor-alpha, recombinant interleukin 10, tolerization techniques for disease-triggering autoantigens, T regulatory cell transfer, vaccination against antigen-specific cytotoxic CD8+ T cells, and gene silencing methods using small inhibitory RNAs are feasible interventions to explore. Treatments directed at dampening immunocy...Continue Reading

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Citations

May 14, 2010·Digestive Diseases and Sciences·Albert J Czaja
Apr 6, 2012·Digestive Diseases and Sciences·Albert J Czaja
Oct 24, 2012·Digestive Diseases and Sciences·Albert J Czaja
Jan 12, 2013·Digestive Diseases and Sciences·Albert J Czaja
Jul 10, 2010·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Luigi MuratoriMarco Lenzi
May 11, 2010·Gastroenterology·Albert J Czaja, Michael P Manns
Sep 10, 2013·Alimentary Pharmacology & Therapeutics·K ZachouL Muratori
Jan 7, 2014·Alimentary Pharmacology & Therapeutics·A J Czaja
Mar 19, 2014·Alimentary Pharmacology & Therapeutics·A J Czaja
Jun 26, 2014·Expert Opinion on Pharmacotherapy·Albert J Czaja
Nov 29, 2011·Best Practice & Research. Clinical Gastroenterology·Albert J Czaja
Apr 14, 2017·Expert Review of Clinical Immunology·Albert J Czaja
Oct 16, 2012·Expert Review of Gastroenterology & Hepatology·Albert J Czaja
Oct 16, 2012·Expert Review of Gastroenterology & Hepatology·Albert J Czaja
Jul 16, 2014·World Journal of Hepatology·Marta Casal MouraGuilherme Macedo
Aug 22, 2014·European Journal of Gastroenterology & Hepatology·Douglas GrunwaldRaza Malik
Oct 23, 2019·Molecular Medicine Reports·Han WangWei Yan
Mar 5, 2014·Clinical Liver Disease·John M Vierling

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