Emerging outcome measures for nutrition trials in the critically ill

Current Opinion in Clinical Nutrition and Metabolic Care
Danielle E BearZudin A Puthucheary

Abstract

Mortality has long been the gold-standard outcome measure for intensive care clinical trials. However, as the critical care community begins to understand and accept that survivorship is associated with functional disability and a health and socioeconomic burden, the clinical and research focus has begun to shift towards long-term physical function RECENT FINDINGS: To use mortality as a primary outcome measure, one would either have to choose an improbable effect (e.g. a difference of 5-10% in mortality as a result of a single intervention) or recruit a larger number of patients, the latter being unfeasible for most critical care trials.Outcome measures will need to match interventions. As an example, amino acids, or intermittent feeding, can stimulate muscle protein synthesis, and so prevention of muscle wasting may seem an appropriate outcome measure when assessing the effectiveness of these interventions. Testing the effectiveness of these interventions requires the development of novel outcome measures that are targeted and acceptable to patients. We describe advancements in dual-energy X-ray absorptiometry scanning, bio-impedence analysis, MRI and muscle ultrasound in this patient group that are beginning to address this d...Continue Reading

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Citations

Dec 27, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Martin Sundström-RehalOlav Rooyackers
Jan 7, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Robert J J van GasselMarcel C G van de Poll
Dec 4, 2019·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·K WittholzA M Deane
Dec 4, 2019·JBI Database of Systematic Reviews and Implementation Reports·Louise AlbrichMary Hickson
Jun 26, 2020·JPEN. Journal of Parenteral and Enteral Nutrition·Kate FetterplaceAdam M Deane
Jan 25, 2020·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Suzan DijkinkInger B Schipper
Feb 21, 2019·Critical Care : the Official Journal of the Critical Care Forum·Danielle E Bear, Zudin A Puthucheary
Dec 15, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Subhal DixitKubilay Demirag
Nov 19, 2020·Nutrients·Marjorie FadeurAnne-Françoise Rousseau

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