Emerging pharmacological strategies in the fight against cocaine addiction

Expert Opinion on Emerging Drugs
Mehmet Sofuoglu, Thomas R Kosten

Abstract

Cocaine addiction continues to be an important public health problem worldwide. At present, there are no proven pharmacotherapies for cocaine addiction. The studies reviewed here revealed a number of emerging targets for cocaine pharmacotherapy. First, disulfiram, a medication with dopaminergic effects, reduced cocaine use in a number of clinical trials. Second, GABA medications, tiagabine and topiramate, were found promising in clinical trials. Third, a beta-adrenergic blocker, propranolol, may be effective especially among cocaine-addicted individuals with high withdrawal severity. Fourth, treatment with a stimulant medication, modafinil, has reduced cocaine use. Last, a cocaine vaccine that slows entry of cocaine into the brain holds promise. These promising findings need to be further tested in controlled clinical trials.

References

Jun 28, 1992·Annals of the New York Academy of Sciences·G F Koob
Nov 1, 1972·The Journal of Pharmacy and Pharmacology·R L HeimansM R Fennessy
Jul 1, 1994·Archives of General Psychiatry·S T HigginsG J Badger
Apr 1, 1997·Addiction·J C Hughes, C C Cook
Jul 1, 1997·Pharmacology, Biochemistry, and Behavior·G F KoobF Weiss
Sep 26, 1997·The Journal of Biological Chemistry·S N NagendraJ V Schloss
Dec 31, 1997·Journal of Clinical Psychopharmacology·J GrabowskiA Korszun
Sep 2, 1998·Synapse·S L DeweyJ D Brodie
Oct 27, 1998·Drug and Alcohol Dependence·E F McCance-KatzP Jatlow
Aug 7, 1999·Primary Care·N L Benowitz
Jan 14, 2000·Journal of Personality Disorders·J PolingE Triffleman
Feb 1, 2000·Journal of Clinical Psychopharmacology·J D RoacheH M Rhoades
Feb 15, 2000·Pharmacology, Biochemistry, and Behavior·M SofuogluD K Hatsukami
May 24, 2000·Drug and Alcohol Dependence·M SofuogluD K Hatsukami
Jul 27, 2000·Current Medicinal Chemistry·W Soudijn, I van Wijngaarden
Dec 1, 2000·The American Journal of Psychiatry·K M KampmanC P O'Brien
Dec 21, 2000·Current Psychiatry Reports·L Siqueland, P Crits-Christoph
May 5, 2001·Expert Opinion on Pharmacotherapy·S C Schachter
Jan 23, 2002·Vaccine·Thomas R KostenBarbara Fox
Feb 14, 2002·Drug and Alcohol Dependence·Michael S CousinsHarriet de Wit
May 1, 2002·Behavioural Pharmacology·C R RushA F Wooten
Jul 30, 2002·Addiction·Maurício Silva de LimaMichael Farrell
Sep 10, 2002·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Karen BrebnerDavid C S Roberts
Sep 11, 2002·Journal of Substance Abuse Treatment·Nancy M Petry, Francis Simcic

❮ Previous
Next ❯

Citations

Oct 26, 2006·Behavior Genetics·Colin N HaileTherese A Kosten
Jan 19, 2012·Journal of Consulting and Clinical Psychology·Nancy M PetryDavid M Ledgerwood
Dec 14, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David Weinshenker, Jason P Schroeder
Jun 15, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Carl L HartRichard W Foltin
Jan 25, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marc N PotenzaJoel Gelernter
Sep 11, 2007·The Australian and New Zealand Journal of Psychiatry·John D SellmanLloyd G Geering
May 22, 2009·Journal of Psychoactive Drugs·Cynthia Geppert, Michael P Bogenschutz
Oct 1, 2013·Journal of Addictive Diseases·Nadine S FarronatoSylvie A Petitjean
May 8, 2013·Journal of Addiction Medicine·Thomas S AtkinsonAlison Oliveto
May 3, 2013·Pharmacogenetics and Genomics·Catherine J SpellicyDavid A Nielsen
Jul 22, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Charles P O'Brien
Sep 2, 2009·Molecular Interventions·Meriem Gaval-Cruz, David Weinshenker
Sep 14, 2007·CNS Drugs·Kevin P Hill, Mehmet Sofuoglu
Jan 9, 2014·Psychopharmacology·Christopher D SchmoutzNicholas E Goeders
Dec 28, 2011·International Review of Psychiatry·Mera S BarrZafiris J Daskalakis
May 23, 2009·The American Journal of Drug and Alcohol Abuse·Colin N HaileTherese A Kosten
Oct 14, 2008·The American Journal of Drug and Alcohol Abuse·Peter T Morgan, Robert T Malison
Nov 28, 2006·The American Journal of Drug and Alcohol Abuse·Mehmet SofuogluThomas Kosten
Aug 22, 2012·Biological Psychiatry·Thomas R KostenDavid A Nielsen
Apr 24, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·C Velázquez-SánchezJ J Canales
Aug 18, 2009·Pharmacology & Therapeutics·Noushin Yahyavi-Firouz-Abadi, Ronald E See
Feb 24, 2009·Psychiatry Research·Karley Y LittleBader Cassin
Jul 22, 2008·Behavioural Brain Research·Bríd A Nic Dhonnchadha, Kathryn A Cunningham
Mar 4, 2008·Sleep Medicine Reviews·Thomas SchierenbeckMagdolna Hornyak
May 14, 2008·Pharmacology, Biochemistry, and Behavior·Mehmet SofuogluThomas Kosten
Dec 25, 2007·La Presse médicale·Laurent KarilaMichel Reynaud
Jan 29, 2008·Pharmacology, Biochemistry, and Behavior·Oné R PagánLilly K Afshari
Oct 31, 2006·Neuropharmacology·T M KorotkovaO A Sergeeva
Apr 17, 2008·British Journal of Pharmacology·D Nutt, A Lingford-Hughes
May 17, 2008·CNS Neuroscience & Therapeutics·Richard P Shank, Bruce E Maryanoff
Aug 19, 2010·The American Journal on Addictions·James PolingMehmet Sofuoglu
Oct 9, 2012·British Journal of Clinical Pharmacology·Ariadna Forray, Mehmet Sofuoglu
Oct 15, 2013·British Journal of Clinical Pharmacology·Alison M DiaperJan K Melichar
Nov 11, 2009·Brain Research·Lisa A Briand, Julie A Blendy
Aug 28, 2007·Biochemical Pharmacology·Judson A Brewer, Marc N Potenza
Nov 12, 2013·Bioorganic & Medicinal Chemistry Letters·William C MotelAndrew Coop
Jun 28, 2012·Neuropharmacology·Mehmet SofuogluKathleen M Carroll
Mar 6, 2013·Neuroscience Letters·Thomas R KostenDavid A Nielsen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.