Emerging pharmacotherapies for adult patients with acute lymphoblastic leukemia.

Clinical Medicine Insights. Oncology
Lydia Lee, Adele K Fielding

Abstract

Acute lymphoblastic leukemia (ALL) treatment regimes are amongst the longest, most intensive and complex used in hematooncology. Despite this, while treatment of pediatric ALL is a success story, we are far from being able to ensure a durable response in adult ALL. This is not due to failure of induction therapy as a complete remission (CR) is achieved in over 90% of patients. However the challenge remains in ensuring a sustained remission. Furthermore in the face of relapsed disease, salvage therapies currently offer a poor chance of a good outcome. This article reviews the novel agents which show the most promise in the treatment of adult ALL.

References

Feb 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H M KantarjianE J Freireich
Jan 9, 2001·Hematology/oncology Clinics of North America·N GökbugetD Messerer
Apr 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·G A KicskaH L Kaufman
May 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles LinkerWillis Navarro
Nov 26, 2002·Hematology·Dieter HoelzerTomasz Szczepański
Mar 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hagop M KantarjianMichael Keating
Jun 5, 2003·International Immunopharmacology·Shanta BantiaRamanda Upshaw
Dec 21, 2004·Clinical and Experimental Immunology·A ChanR Gold
Feb 22, 2005·Cancer Chemotherapy and Pharmacology·Todd CooperVarsha Gandhi
Mar 22, 2005·British Journal of Pharmacology·Elaine M BreslinPaul Brennan
May 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J KurtzbergB S Mitchell
Apr 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sima JehaPeter Steinherz
May 6, 2006·Blood·Blanca Sanchez-GonzalezGuillermo Garcia-Manero
Jun 7, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas M HabermannSandra J Horning
Aug 11, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Francis GilesKapil Bhalla
Sep 5, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Karen W L YeeFrancis J Giles
Jan 6, 2007·Leukemia·D AuclairS M Wilhelm
Feb 27, 2007·Cell·Aaron D GoldbergEmily Bernstein
Feb 27, 2007·Cell·Peter A Jones, Stephen B Baylin
Feb 28, 2007·Leukemia & Lymphoma·Myron S CzuczmanUNKNOWN Cancer and Leukemia Group B
Sep 18, 2007·Nature Medicine·Teresa PalomeroAdolfo A Ferrando
Jan 31, 2008·Journal of the National Cancer Institute·Weiguo ZhangMichael Andreeff
Mar 25, 2008·Lancet·Ching-Hon PuiA Thomas Look
May 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David A RizzieriFrancis J Giles

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Citations

Oct 6, 2017·Oncotarget·Friederike FeldmannSimone Fulda
Dec 29, 2019·European Journal of Medicinal Chemistry·Nazarii SabatNadège Lubin-Germain

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