Emerging role of autoantibodies against appetite-regulating neuropeptides in eating disorders

Nutrition
Sergueï O FetissovPierre Déchelotte

Abstract

Recent findings of autoantibodies directed against melanocortin peptides suggest that these autoantibodies may represent a source of variability in peptidergic signaling that can be responsible for altered appetite and emotion in eating disorders. However, it is still unknown if autoantibodies directed against some other appetite-regulating neuropeptides and peptide hormones exist in healthy human subjects and if these autoantibodies can regulate appetite and emotion. We determined the presence of autoantibodies against some key appetite-regulating neuropeptides and peptide hormones in sera of human subjects and in rats, and used animal models to study the role of alpha-melanocyte-stimulating hormone autoantibodies in food intake and anxiety. Immunoglobulin G and A autoantibodies against alpha-melanocyte-stimulating hormone, neuropeptide Y, agouti-related protein, ghrelin, leptin, and some other neuropeptides or peptide hormones involved in appetite control were present in healthy humans and rats. Animal models including active and passive transfer showed that alpha-melanocyte-stimulating hormone autoantibodies are involved in the regulation of feeding and anxiety. Sequence homology was found between neuropeptides and proteins ...Continue Reading

References

Jul 1, 1969·The Journal of Clinical Investigation·G F Springer, R E Horton
Jun 5, 1998·Immunology Today·K BendtzenM Svenson
May 28, 2004·Nature Immunology·Lawrence Steinman
Jan 5, 2005·Molecular Psychiatry·T Kishi, J K Elmquist
Apr 28, 2005·Nature Neuroscience·Roger D Cone
Oct 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sergueï O FetissovTomas Hökfelt
Aug 1, 2006·Biological Psychiatry·Sergueï O FetissovTomas Hökfelt
Oct 25, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Peter AchenbachEzio Bonifacio
Apr 11, 2007·Acta Neurologica Scandinavica. Supplementum·T Holmøy
Oct 2, 2007·Current Opinion in Gastroenterology·Andrew J Macpherson, Emma Slack
Dec 13, 2007·Nature Reviews. Neuroscience·Robert DantzerKeith W Kelley
Jun 11, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Sergueï O Fetissov, Pierre Déchelotte
Jul 30, 2008·Nutrition·Melissa J S Chee, William F Colmers
Jul 30, 2008·Nutrition·Alessandro LavianoFilippo Rossi Fanelli
Jul 30, 2008·Nutrition·Karl G HofbauerJean-Christophe Peter
Aug 30, 2008·Nutrition·John E Morley, Susan A Farr
Aug 30, 2008·Nutrition·Stephen C BenoitDeborah J Clegg
Aug 30, 2008·Nutrition·Tomas HökfeltKarl H Pfenninger

❮ Previous
Next ❯

Citations

Aug 13, 2011·Current Opinion in Clinical Nutrition and Metabolic Care·Sergueï O Fetissov, Pierre Déchelotte
Sep 29, 2011·International Journal of Peptides·Yolanda Diz-Chaves
May 29, 2012·Cellular and Molecular Life Sciences : CMLS·Paul Forsythe, Wolfgang A Kunze
Feb 10, 2016·Nutrition·Marie FrançoisSergueï O Fetissov
Mar 12, 2011·Nutrition·Mutsumi TerashiSergueï O Fetissov
Jul 1, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B OhlssonG N Fredrikson
Jun 7, 2011·Psychoneuroendocrinology·Quentin CoquerelSergueï O Fetissov
Aug 27, 2011·Nutrition·Kazuma OgisoAkio Inui
Jun 16, 2011·Peptides·Syrine Gallas, Sergueï O Fetissov
May 10, 2017·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Jamie E TemkoLorenzo Leggio
Sep 5, 2018·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Anna HedmanCynthia M Bulik
Jul 29, 2010·Physiological Reviews·Inna SekirovB Brett Finlay
Feb 14, 2017·Frontiers in Endocrinology·Sergueï O FetissovRomain Legrand
Jan 9, 2021·European Psychiatry : the Journal of the Association of European Psychiatrists·Elvira Anna CarboneCristina Segura-Garcia
Dec 29, 2020·Journal of Neurochemistry·Rubén García-CabrerizoJohn F Cryan
Aug 28, 2021·International Journal of Molecular Sciences·Andrzej LewińskiRenata Stawerska

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Related Papers

Current Opinion in Clinical Nutrition and Metabolic Care
Sergueï O Fetissov, Pierre Déchelotte
Psychoneuroendocrinology
Maria Hamze SinnoSergueï O Fetissov
Proceedings of the National Academy of Sciences of the United States of America
Sergueï O FetissovTomas Hökfelt
© 2022 Meta ULC. All rights reserved