Emerging role of circadian clock disruption in alcohol-induced liver disease.

American Journal of Physiology. Gastrointestinal and Liver Physiology
Shannon M Bailey

Abstract

The detrimental health effects of excessive alcohol consumption are well documented. Alcohol-induced liver disease (ALD) is the leading cause of death from chronic alcohol use. As with many diseases, the etiology of ALD is influenced by how the liver responds to other secondary insults. The molecular circadian clock is an intrinsic cellular timing system that helps organisms adapt and synchronize metabolism to changes in their environment. The clock also influences how tissues respond to toxic, environmental, and metabolic stressors, like alcohol. Consistent with the essential role for clocks in maintaining health, genetic and environmental disruption of the circadian clock contributes to disease. While a large amount of rich literature is available showing that alcohol disrupts circadian-driven behaviors and that circadian clock disruption increases alcohol drinking and preference, very little is known about the role circadian clocks play in alcohol-induced tissue injuries. In this review, recent studies examining the effect alcohol has on the circadian clock in peripheral tissues (liver and intestine) and the impact circadian clock disruption has on development of ALD are presented. This review also highlights some of the rhy...Continue Reading

References

Mar 5, 2002·The Journal of Biological Chemistry·Erik J EideDavid M Virshup
May 23, 2002·Cell·Satchidananda PandaJohn B Hogenesch
Feb 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Seung-Hee YooJoseph S Takahashi
Jun 15, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Min You, David W Crabb
Apr 23, 2005·Science·Fred W TurekJoseph Bass
Mar 31, 2006·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Tracey A YoungCarol C Cunningham
Aug 23, 2006·Cell·Xiaoyong YangRonald M Evans
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Junichiro SonodaRonald M Evans
Nov 7, 2007·Cell Metabolism·Akira KohsakaJoseph Bass
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·B KornmannU Schibler
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·D M VirshupE Vielhaber Harnish
Jun 11, 2008·The American Journal of Clinical Nutrition·Silvia SookoianCarlos Jose Pirola
Apr 3, 2009·Journal of Circadian Rhythms·Takashi KudoShigenobu Shibata
Jun 18, 2010·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Leena KovanenTimo Partonen
Aug 3, 2010·Cell Metabolism·Xiaoyue PanM Mahmood Hussain
Apr 6, 2011·Alcoholism, Clinical and Experimental Research·Garth SwansonAli Keshavarzian
May 7, 2011·Journal of Gastroenterology and Hepatology·Devanshi SethChristopher P Day
Jan 21, 2012·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Peng ChenJianfa Zhang
Apr 10, 2012·Annual Review of Neuroscience·Jennifer A MohawkJoseph S Takahashi
Sep 5, 2012·The Journal of Clinical Investigation·Jan PetrasekGyongyi Szabo
Sep 13, 2012·Biochimica Et Biophysica Acta·Maayan BarneaOren Froy
May 22, 2013·Biochemical Pharmacology·Brice SidPedro Buc Calderon
Jan 17, 2014·Scientific Reports·Peng ZhouGiles E Duffield
Mar 13, 2014·Annual Review of Biochemistry·Akhilesh B Reddy, Guillaume Rey
Apr 30, 2014·Behavioral Neuroscience·Amanda S Damaggio, Michael R Gorman
Sep 13, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sang Min LeeLi Wang
Sep 13, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yuyan HanGianfranco Alpini

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BETA
acetylation

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