Emerging Role of Circular RNAs in Cancer

Frontiers in Oncology
Jing LiuHui Li

Abstract

Circular RNAs (circRNAs), which are generated mainly from back-splicing of exons in precursor mRNAs (pre-mRNAs), are a novel class of endogenous covalently closed RNA molecules. Their functions as microRNA sponges, protein scaffolds, and modulators of transcription and splicing, as well as occasional templates for polypeptide production, are beginning to be recognized, though the investigation of circRNAs is in its infancy. circRNAs play critical roles in diverse cellular processes. Aberrant expression of circRNAs in malignancies sustains cellular growth and proliferation, promotes cellular invasiveness, and circumvents cellular senescence and death, suggesting their potential for exploitation as clinical biomarkers and therapeutic targets. In this review, we highlight recent progress in research on circRNAs in cancer, emphasizing the molecular mechanisms and potential clinical value of circRNAs.

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Citations

Feb 11, 2021·Briefings in Functional Genomics·Valentina MianoIsaia Barbieri
Feb 23, 2021·Frontiers in Cell and Developmental Biology·Sabah NisarMohammad Haris
May 19, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiao LiZhouxiao Li
Jul 21, 2021·International Journal of Molecular Sciences·Golam RbbaniJorge M O Fernandes
Aug 8, 2021·International Journal of Molecular Sciences·Valeria PietropaoloUgo Moens
Aug 17, 2021·Clinical and Experimental Hypertension : CHE·Xin HeLina Zhang

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Methods Mentioned

BETA
electron microscopy
transfection
biopsy
RNA-seq

Software Mentioned

CircPanel
RPAD

Related Concepts