Emerging role of epoxyeicosatrienoic acids in coronary vascular function

European Journal of Clinical Investigation
Brandon T LarsenOssama A Hatoum

Abstract

The importance of endothelium-derived nitric oxide in coronary vascular regulation is well-established and the loss of this vasodilator compound is associated with endothelial dysfunction, tissue hypoperfusion and atherosclerosis. Numerous studies indicate that the endothelium produces another class of compounds, the epoxyeicosatrienoic acids (EETs), which may partially compensate for the loss of nitric oxide in cardiovascular disease. The EETs are endogenous lipids which are derived through the metabolism of arachidonic acid by cytochrome P450 epoxygenase enzymes. Also, EETs hyperpolarize vascular smooth muscle and induce dilation of coronary arteries and arterioles, and therefore may be endogenous mediators of coronary vasomotor tone and myocardial perfusion. In addition, EETs have been shown to inhibit vascular smooth muscle migration, decrease inflammation, inhibit platelet aggregation and decrease adhesion molecule expression, therefore representing an endogenous protective mechanism against atherosclerosis. Endogenous EETs are degraded to less active dihydroxyeicosatrienoic acids by soluble epoxide hydrolase. Pharmacological inhibition of soluble epoxide hydrolase has received considerable attention as a potential approac...Continue Reading

References

Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·F CatellaG A FitzGerald
Mar 30, 1990·Biochemical and Biophysical Research Communications·W K LinP Y Wong
Jan 19, 1995·The American Journal of Cardiology·J R Vane, R M Botting
Nov 1, 1996·Journal of the American Society of Nephrology : JASN·J D ImigJ R Falck
Feb 12, 1998·The Journal of Clinical Investigation·L Urakami-HarasawaA Takeshita
Oct 16, 1999·Nature·B FisslthalerR Busse
Feb 9, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·D ZhuE R Jacobs
Jun 22, 2000·The Journal of Biological Chemistry·M SandbergC J Omiecinski
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·D ZhuE R Jacobs
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·Y ZhangM VanRollins
Oct 13, 2001·Circulation Research·S T Davidge
Feb 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Benjamin B DavisRobert H Weiss
Feb 22, 2002·Current Opinion in Nephrology and Hypertension·William B Campbell, Kathryn M Gauthier
Mar 15, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Pin-Lan LiWilliam B Campbell
Mar 20, 2002·Molecular Pharmacology·Lorraine M KingDarryl C Zeldin
May 15, 2002·Biochemical Pharmacology·Christophe MorisseauBruce D Hammock

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Citations

Dec 16, 2011·Journal of Medicinal Chemistry·Hong C Shen, Bruce D Hammock
Jul 21, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jin-Young LeeJin-Ho Chung
May 1, 2008·The Journal of Pharmacology and Experimental Therapeutics·Houli JiangJohn C McGiff
Oct 30, 2010·The Journal of Pharmacology and Experimental Therapeutics·Chen ChenDao Wen Wang
Feb 3, 2012·Physiological Reviews·John D Imig
May 15, 2008·Blood·Anne C FreiNancy J Wandersee
Mar 6, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Priyanka SuraDavid F Grant
Mar 1, 2011·Translational Stroke Research·Shehnaz SultanaPardhananda Reddy Penagaluru
Jul 16, 2009·Drug Metabolism Reviews·Margherita Strolin BenedettiJean-Baptiste Watelet
Oct 6, 2011·Molecular Pain·Christian BrenneisKlaus Scholich
Dec 1, 2010·Pharmacology & Therapeutics·Andrew MacKenzie
Mar 17, 2009·Journal of Molecular and Cellular Cardiology·D KatragaddaJ M Seubert
Dec 8, 2006·Trends in Pharmacological Sciences·Brandon T LarsenDavid D Gutterman
Jun 15, 2007·British Journal of Pharmacology·H JiangJ C McGiff
May 4, 2010·Cardiovascular Therapeutics·Hong QiuNipavan Chiamvimonvat
Jan 29, 2011·Congestive Heart Failure·Ning LiNipavan Chiamvimonvat
Dec 24, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Xingyang YiLifen Chi
Oct 6, 2017·Antioxidants & Redox Signaling·Ana Carolina AraújoJesper Z Haeggström
May 1, 2010·Expert Opinion on Therapeutic Patents·Hong C Shen
Dec 22, 2015·Journal of Atherosclerosis and Thrombosis·Xingyang YiChun Wang
Apr 17, 2019·Experimental and Therapeutic Medicine·Na DaiMinmin Wang
May 10, 2017·Journal of Cardiovascular Pharmacology·Julie K Freed, David D Gutterman
Feb 20, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Shane A Phillips
Dec 25, 2019·Molecular Diversity·Elham RezaeeSayyed Abbas Tabatabai

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