Emerging role of extracellular vesicles in mediating cancer cachexia

Biochemical Society Transactions
Sai V ChittiSuresh Mathivanan

Abstract

Cancer cachexia is a multifactorial metabolic syndrome characterized by the rapid loss of skeletal muscle mass with or without the loss of fat mass. Nearly 50-80% of all cancer patients' experience rapid weight loss results in ∼20% of cancer-related deaths. The levels of pro-inflammatory and pro-cachectic factors were significantly up-regulated in cachexia patients when compared with the patients who were without cachexia. It is becoming evident that these factors work synergistically to induce cancer cachexia. Extracellular vesicles (EVs) including exosomes and microvesicles are implicated in cell-cell communication, immune response, tissue repair, epigenetic regulation, and in various diseases including cancer. It has been reported that these EVs regulate cancer progression, metastasis, organotropism and chemoresistance. In recent times, the role of EVs in regulating cancer cachexia is beginning to unravel. The aim of this mini article is to review the recent knowledge gained in the field of EVs and cancer cachexia. Specifically, the role of tumour cell-derived EVs in promoting catabolism in distally located skeletal muscles and adipose tissue will be discussed.

References

Jan 1, 1980·Journal of Surgical Oncology·L Houten, A A Reilley
Apr 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J Paul MonkMiguel A Villalona-Calero
Jan 16, 2009·Trends in Cell Biology·Emanuele CocucciJacopo Meldolesi
Apr 4, 2009·Physiological Reviews·Michael J Tisdale
Aug 12, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Aminah JatoiCharles L Loprinzi
Jul 6, 2010·Journal of Proteomics·Suresh MathivananRichard J Simpson
Aug 25, 2010·Current Opinion in Supportive and Palliative Care·Benjamin H L Tan, Kenneth C H Fearon
Feb 8, 2011·The Lancet Oncology·Kenneth FearonVickie E Baracos
Jul 16, 2011·Gastroenterology Research and Practice·Claire L DonohoeJohn V Reynolds
Oct 26, 2011·The International Journal of Biochemistry & Cell Biology·Anna-Kristin Ludwig, Bernd Giebel
Apr 6, 2012·Journal of Cachexia, Sarcopenia and Muscle·Kunihiro Sakuma, Akihiko Yamaguchi
Oct 4, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Shin-ichiro OhnoMasahiko Kuroda
Dec 5, 2012·Nature Reviews. Clinical Oncology·Kenneth FearonVickie Baracos
Jun 5, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Theodore P BraunDaniel L Marks
Oct 24, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Marian AalbertsWillem Stoorvogel
Dec 12, 2013·American Journal of Physiology. Endocrinology and Metabolism·Agné KulytéIngrid Dahlman
Jan 1, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Justin L ChenPaul Gregorevic
Feb 19, 2014·Nature Reviews. Rheumatology·Edit I BuzasSteffen Gay
Mar 13, 2014·Proceedings of the National Academy of Sciences of the United States of America·Wei A HeCarlo M Croce
May 20, 2014·Trends in Molecular Medicine·Kate M Candelario, Dennis A Steindler
May 31, 2014·BioMed Research International·Jill K Onesti, Denis C Guttridge
Jul 22, 2014·Cell Metabolism·Michele PetruzzelliErwin F Wagner
Aug 16, 2014·Drugs in Context·Susan Tsivitse ArthurChristopher M Blanchette
Sep 7, 2014·Journal of Cachexia, Sarcopenia and Muscle·Stefan D Anker, Stephan von Haehling
Oct 8, 2014·Nature Reviews. Cancer·Josep M ArgilésFrancisco J López-Soriano
Nov 12, 2014·Journal of Cachexia, Sarcopenia and Muscle·Stephan von Haehling, Stefan D Anker
Jan 17, 2015·Cancer Treatment Reviews·Lauren MacDonaghMartin P Barr
Apr 25, 2015·Methods : a Companion to Methods in Enzymology·Todd A LydicGavin E Reid
Jun 11, 2015·Gut·Gunisha SagarDebabrata Mukhopadhyay
Jun 21, 2015·The Journal of Biological Chemistry·Danielle N SetoRobert W Jackman
Sep 12, 2015·Cell·Amelia J JohnstonNicholas J Hoogenraad
Oct 28, 2015·Mediators of Inflammation·Rodolfo Gonzalez CamargoMarília Seelaender
Nov 3, 2015·Nature·Ayuko HoshinoDavid Lyden
Nov 12, 2015·Autoimmunity Reviews·Delphine TurpinPierre Duffau
Dec 15, 2015·Nature·Corie Lok
Feb 11, 2016·International Journal of Molecular Sciences·Hina KalraSuresh Mathivanan
Feb 24, 2016·Oncogenesis·P E Porporato
Mar 6, 2016·Genes & Development·Michele Petruzzelli, Erwin F Wagner
Aug 10, 2016·Cancer Cell·Candia M KenificDavid Lyden
Dec 7, 2016·Life Sciences·Hetal J Patel, Bhoomika M Patel

❮ Previous
Next ❯

Citations

Aug 21, 2019·Communications Biology·Kening ZhaoSuresh Mathivanan
Apr 25, 2020·International Journal of Molecular Sciences·Yong Qin KohAlexandre Chan
Feb 8, 2020·Science·Raghu Kalluri, Valerie S LeBleu
Jan 16, 2021·Diagnostics·Emanuele BerardiDario Coletti
Jan 12, 2020·Communications Biology·Kening ZhaoSuresh Mathivanan
Oct 17, 2020·Pharmaceutical Research·Menchus Quan, Shihuan Kuang
May 18, 2021·Non-coding RNA Research·Guannan DuYi Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Related Papers

Nature Reviews. Cancer
Josep M ArgilésFrancisco Javier López-Soriano
Trends in Molecular Medicine
Pieter VaderMatthew J A Wood
Nestlé Nutrition Workshop Series. Clinical & Performance Programme
M J Tisdale
© 2022 Meta ULC. All rights reserved