Emerging role of ILK and ELMO2 in the integration of adhesion and migration pathways.

Cell Adhesion & Migration
Ernest Ho, Lina Dagnino

Abstract

Integrins and their associated proteins are essential components of the cellular machinery that modulates adhesion and migration. In particular, integrin-linked kinase (ILK), which binds to the cytoplasmic tail of β1 integrins, is required for migration in a variety of cell types. We previously identified engulfment and motility 2 (ELMO2) as an ILK-binding protein in epidermal keratinocytes. Recently, we investigated the biological role of the ILK/ELMO2 complexes, and found that they exist in the cytoplasm. ILK/ELMO2 species are recruited by active RhoG to the plasma membrane, where they induce Rac1 activation and formation of lamellipodia at the leading edge of migrating cells. A large number of growth factors and cytokines induce keratinocyte migration. However, we found that formation of RhoG/ELMO2/ILK complexes occurs selectively upon stimulation by epidermal growth factor, but not by transforming growth factor-β1 or keratinocyte growth factor. Herein we discuss the relevance of these complexes to our understanding of the molecular mechanisms involved in cell migration, as well as their potential functions in morphogenesis and tissue regeneration following injury.

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Citations

Oct 1, 2014·The Journal of Investigative Dermatology·Linda ViLina Dagnino
May 23, 2015·Molecular Biology of the Cell·Bradley C JacksonLina Dagnino
Dec 29, 2013·Molecular Biology of the Cell·Alena RudkouskayaLina Dagnino
Nov 5, 2016·Biochimica Et Biophysica Acta·Ernest HoLina Dagnino
Nov 25, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Samar SayedyahosseinLina Dagnino
Jan 13, 2015·The Journal of Biological Chemistry·Yingmin SunKeyong Du

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