Emerging role of immunotherapy for childhood cancers

Chinese Clinical Oncology
Rupert Handgretinger, Patrick Schlegel

Abstract

Recent developments in cell and gene therapy have a great impact on the new therapeutic approaches in pediatric cancers. Monoclonal antibodies for neuroblastoma and bispecific antibodies for leukemia have induced significant clinical responses for otherwise chemorefractory patients. Moreover, cellular therapeutic approaches including chimeric antigen receptor (CAR) T-cells as well as natural killer (NK) cells have the potential to cure patients with so far incurable malignancies and are the basis for future new therapies for pediatric cancer. Newer generations of cellular therapies, further development and improvement of such new strategies and their earlier use in therapeutic strategies will hopefully allow to significantly reduce the chemotherapeutic burden for children with cancer while increasing the cure rate.

Citations

Dec 13, 2019·Cancer Metastasis Reviews·Brian HutzenTimothy P Cripe
Jan 22, 2019·Cell Medicine·Diane SeimetzJan Richter

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Antibody Engineering

Antibody engineering technologies are constantly advancing to improve the clinical effectiveness of monoclonal and bispecific antibodies. Discover the latest research on Antibody Engineering here.