Emerging Role of Janus Kinase Inhibitors for the Treatment of Atopic Dermatitis

ImmunoTargets and Therapy
Rhea SinghSteven R Feldman

Abstract

Atopic dermatitis (AD) is a common chronic, inflammatory skin condition. The pathogenesis of AD involves many cytokines that utilize the Janus kinase/signal transducer and activator of transcription (JAK-STAT) signaling cascade; therefore, JAK inhibitors may be used in the treatment of AD. This review aims to evaluate the pathophysiology, efficacy, and safety of JAK inhibitors and their emerging role as a therapeutic option for patients with AD. A PubMed search of Phase I, II, and III clinical trials was conducted for relevant literature published between January 2015 and June 2020 utilizing the key terms: JAK inhibitors, atopic dermatitis, efficacy, safety, and treatment. The search was subsequently expanded to include additional terms. In multiple Phase II and III clinical trials, JAK inhibitors were more efficacious than placebo or vehicle controls and slightly more efficacious in direct comparisons to corticosteroids. Overall, JAK inhibitors have a moderate safety profile for use in AD. Some of the more severe theoretical adverse events included thrombosis and reactivation of viral infections. While data remain limited for the long-term efficacy and safety of JAK inhibitor use in patients with AD, many ongoing clinical tria...Continue Reading

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Citations

Jan 8, 2021·Therapeutics and Clinical Risk Management·Celina DubinEmma Guttman-Yassky
Jun 2, 2021·The Medical Clinics of North America·Cynthia X Chan, Kathryn A Zug
Aug 28, 2021·Biomedicines·Seok-Young KangHye-One Kim
Oct 13, 2021·Expert Review of Clinical Immunology·Mohammad I FardosSteven R Feldman

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Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

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