Apr 4, 2017

Emerging role of mitophagy in human diseases and physiology

BMB Reports
Jee-Hyun Um, Jeanho Yun

Abstract

Mitophagy is a process of selective removal of damaged or unnecessary mitochondria using autophagic machinery. Mitophagy plays an essential role in maintaining mitochondrial quality control and homeostasis. Mitochondrial dysfunctions and defective mitophagy in neurodegenerative diseases, cancer, and metabolic diseases indicate a close link between human disease and mitophagy. Furthermore, recent studies showing the involvement of mitophagy in differentiation and development, suggest that mitophagy may play a more active role in controlling cellular functions. A better understanding of mitophagy will provide insights about human disease and offer novel chance for treatment. This review mainly focuses on the recent implications for mitophagy in human diseases and normal physiology. [BMB Reports 2017; 50(6): 299-307].

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Mentioned in this Paper

Study
Dilated Cardiomyopathy, Neutropenia, Skeletal Myopathy, and Abnormal Mitochondria
Degenerative Diseases, Spinal Cord
Nerve Degeneration
Cell Differentiation Process
Mitochondria
Programmed Cell Death, Type II
Multiple Mitochondrial Dysfunctions Syndrome 1
Mitochondrial Degradation
Malignant Neoplasms

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