Emerging role of prodromal headache in patients with anti-N-methyl-D-aspartate receptor encephalitis

Journal of Pain Research
Congcong MaYajun Lian

Abstract

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis patients often present with psychiatric symptoms, cognitive dysfunction, epilepsy and memory deficits. A previous study has suggested that headache can occurr during the early stages of anti-NMDAR encephalitis. However, the exact association between headache and anti-NMDAR encephalitis has hardly been investigated, apart from a few case studies. This is probably due to the severity of encephalitis symptoms, and the mechanism underlying headache-associated anti-NMDAR encephalitis remains largely unclear. This study aimed to investigate the role of prodromal headache in 28 patients diagnosed with anti-NMDAR encephalitis. Clinical data related to the prodromal headache characteristics of anti-NMDAR encephalitis patients were prospectively collected from January first 2017 to June first 2018. Autoimmune antibodies in the cerebrospinal fluid (CSF) of anti-NMDAR encephalitis patients were detected by an indirect immunofluorescence staining kit. The differences between age, sex, clinical symptoms (fever, epilepsy, psychiatric symptoms, cognitive impairment, disturbance of consciousness), CSF, brain MRI abnormalities, and modified Rankin Scale (mRS) score were compared between pat...Continue Reading

Citations

Jan 15, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A N BelovaA N Boyko
Jul 18, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A N BelovaA N Boyko
Sep 13, 2020·The Journal of Emergency Medicine·Dylan NortonDavid Gill

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