Emerging roles for scavenger receptor SREC-I in immunity

Cytokine
Ayesha MurshidStuart K Calderwood

Abstract

SREC-I is a class F scavenger receptor with key role in the immune response, particularly in antigen presenting cell (APC) such as macrophages and dendritic cells (DC). This receptor is able to mediate engulfment of dead cells as well as endocytosis of heat shock protein (HSP)-antigen complexes. SREC-I could thus potentially mediate the tolerizing influence of apoptotic cells or the immunostimulatory effects of HSP-peptide complexes, depending on context. This receptor was able to mediate presentation of external antigens, bound to HSPs through both the class II pathway as well as cross presentation via MHC class I complexes. In addition to its recently established role in adaptive immunity, emerging studies are indicating a broad role in innate immunity and regulation of cell signaling through Toll Like Receptors (TLR). SREC-I may thus play a key role in APC function by coordinating immune responses to internal and external antigens in APC.

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Citations

Dec 20, 2015·Immunological Reviews·Kristen K Penberthy, Kodi S Ravichandran
May 21, 2016·Frontiers in Immunology·Stuart K CalderwoodAyesha Murshid
May 21, 2016·Frontiers in Immunology·Maxim Shevtsov, Gabriele Multhoff
Oct 22, 2016·Trends in Microbiology·Michelle E Mulcahy, Rachel M McLoughlin
Dec 6, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Maxim ShevtsovGabriele Multhoff
Mar 7, 2020·International Reviews of Immunology·Vijay Kumar
Jul 9, 2021·Investigative Ophthalmology & Visual Science·Ranran ZhangGuiqiu Zhao

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