Dec 22, 2010

Emerging roles for the transforming growth factor-{beta} superfamily in regulating adiposity and energy expenditure

Endocrine Reviews
Nader Zamani, Chester W Brown


Members of the TGF-β superfamily regulate many aspects of development, including adipogenesis. Studies in cells and animal models have characterized the effects of superfamily signaling on adipocyte development, adiposity, and energy expenditure. Although bone morphogenetic protein (BMP) 4 is generally considered a protein that promotes the differentiation of white adipocytes, BMP7 has emerged as a selective regulator of brown adipogenesis. Conversely, TGF-β and activin A inhibit adipocyte development, a process augmented in TGF-β-treated cells by Smads 6 and 7, negative regulators of canonical TGF-β signaling. Other superfamily members have mixed effects on adipogenesis depending on cell culture conditions, the timing of expression, and the cell type, and many of these effects occur by altering the expression or activities of proteins that control the adipogenic cascade, including members of the CCAAT/enhancer binding protein family and peroxisome proliferator-activated receptor-γ. BMP7, growth differentiation factor (GDF) 8, and GDF3 are versatile in their mechanisms of action, and altering their normal expression characteristics has significant effects on adiposity in vivo. In addition to their roles in adipogenesis, activin...Continue Reading

  • References151
  • Citations59
  • References151
  • Citations59


Mentioned in this Paper

Recombinant Transforming Growth Factor
Transforming Growth Factor beta
MSTN gene
Enhancer Binding Protein
Adipocytes, White
Protein-Energy Malnutrition
Energy Metabolism
Cell Culture Techniques
PPARA gene

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