Emerging Roles of Air Gases in Lipid Bilayers

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Chia-Wei LeeIng-Shouh Hwang

Abstract

Recent studies indicate that changing the physical properties of lipid bilayers may profoundly change the function of membrane proteins. Here, the effects of dissolved nitrogen and oxygen molecules on the mechanical properties and stability of lipid bilayers are investigated using differential confocal microscopy, atomic force microscopy, and molecular dynamics simulations. All experiments evidence the presence of dissolved air gas in lipid bilayers prepared without gas control. The lipid bilayers in degassed solutions are softer and less stable than those in ambient solutions. High concentrations of nitrogen increase the bending moduli and stability of the lipid bilayers and impede phase separation in ternary lipid bilayers. The effect of oxygen is less prominent. Molecular dynamics simulations indicate that higher nitrogen affinity accounts for increased rigidity. These findings have fundamental and wide implications for phenomena related to lipid bilayers and cell membranes, including the origin of life.

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Citations

Jun 27, 2020·Journal of Chemical Information and Modeling·Yue ZhangQing-Chuan Zheng
Dec 23, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Ya-Ling ChiangIng-Shouh Hwang

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