Emerging roles of long non-coding RNA in cancer

Cancer Science
Anna Sanchez CalleTakahiro Ochiya

Abstract

Since comprehensive analysis of the mammalian genome revealed that the majority of genomic products are transcribed in long non-coding RNA (lncRNA), increasing attention has been paid to these transcripts. The applied next-generation sequencing technologies have provided accumulating evidence of dysregulated lncRNA in cancer. The implication of this finding can be seen in many forms and at multiple levels. With impacts ranging from integrating chromatin remodeling complexes to regulating transcription and post-transcriptional processes, aberrant expression of lncRNA may have repercussions in cell proliferation, tumor progression or metastasis. lncRNA may act as enhancers, scaffolds or decoys by physically interacting with other RNA species or proteins, resulting in a direct impact on cell signaling cascades. Even though their functional classification is well-established in the context of cancer, clearer characterization in terms of their phenotypic outputs is needed to optimize and identify suitable candidates that enable the development of new therapeutic strategies and the design of novel diagnostic approaches. The present article aims to outline different cancer-associated lncRNA according to their contribution to tumor sup...Continue Reading

References

Dec 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Francisco X Real
Jun 25, 2010·Cold Spring Harbor Perspectives in Biology·Archa H Fox, Angus I Lamond
Aug 13, 2010·Pigment Cell & Melanoma Research·Meifan Chen
May 27, 2011·Nature Genetics·Matthew L FreedmanIan G Mills
Sep 8, 2012·Nature·Sarah DjebaliThomas R Gingeras
Jul 6, 2013·Cell·Igor Ulitsky, David P Bartel
Sep 10, 2013·Clinical Colorectal Cancer·Haiyan ZhaiJingfang Ju
Oct 10, 2013·Nature Reviews. Molecular Cell Biology·Sarah Geisler, Jeff Coller
Jan 1, 2011·Cancers·Toshinori Ozaki, Akira Nakagawara
Mar 29, 2014·Nature·Alistair R R ForrestYoshihide Hayashizaki
Jul 22, 2014·Nature·Yuen-Yi TsengAnindya Bagchi
Dec 20, 2014·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Didier MeseureAndre Nicolas
Jan 20, 2015·Nature Genetics·Matthew K IyerArul M Chinnaiyan
Aug 9, 2015·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Michiel de HoonPiero Carninci
Dec 19, 2015·Nature Reviews. Cancer·Luis C FernándezFrancisco X Real
Dec 25, 2015·Genes & Development·Gayatri ArunDavid L Spector
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yaoyong LuRongwei Liao
May 6, 2016·Gene Regulation and Systems Biology·Hao KeBaowei Jiao
May 10, 2016·Trends in Genetics : TIG·Andrea Ventura
Jun 9, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Shaorong ZhangJingying Liu

❮ Previous
Next ❯

Citations

Apr 16, 2019·Technology in Cancer Research & Treatment·Tianzhu ZhangZhongxin Lu
Jul 3, 2019·Proceedings of the National Academy of Sciences of the United States of America·Chenfeng WangYide Mei
Nov 7, 2019·Journal of Cellular Biochemistry·Yiqing LaiLina Zhang
Mar 17, 2020·Journal of Cellular and Molecular Medicine·Shidai JinWen Gao
Jul 13, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chengle ZhuangYaoting Gui
Mar 1, 2019·Cancers·Shang-Gin WuJin-Yuan Shih
Sep 29, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Qiansheng ZhangLaijun Song
Feb 23, 2020·Frontiers in Genetics·Lihong PengLiqian Zhou
Apr 21, 2020·Pharmacogenomics and Personalized Medicine·Jang Hee HongJae Kyu Sung
Aug 21, 2020·Journal of Cellular and Molecular Medicine·Yan ZhangLin Mao
Jan 19, 2019·Genes·Sorina DinescuMarieta Costache
Nov 12, 2019·Frontiers in Molecular Biosciences·Fatemeh HashemianMohammad Taheri
Mar 19, 2020·Digestive Diseases and Sciences·Mina KhajehdehiMehdi Damaghi

❮ Previous
Next ❯

Methods Mentioned

BETA
acetylation
xenograft

Software Mentioned

ENCODE
FANTOM

Related Concepts

Related Feeds

Cancer Sequencing

Several sequencing approaches are employed to understand and examine tumor development and progression. These include whole genome as well as RNA sequencing. Here is the latest research on cancer sequencing.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Cancer Epigenetics Chromatin Complexes (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on chromatin complexes and their role in cancer epigenetics.

Cancer Epigenetics and Chromatin (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on chromatin and its role in cancer epigenetics please follow this feed to learn more.