Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection

Progress in Neurobiology
Meijuan ZhangFeng Zhang

Abstract

Phase II metabolic enzymes are a battery of critical proteins that detoxify xenobiotics by increasing their hydrophilicity and enhancing their disposal. These enzymes have long been studied for their preventative and protective effects against mutagens and carcinogens and for their regulation via the Keap1 (Kelch-like ECH associated protein 1)/Nrf2 (Nuclear factor erythroid 2 related factor 2)/ARE (antioxidant response elements) pathway. Recently, a series of studies have reported the altered expression of phase II genes in postmortem tissue of patients with various neurological diseases. These observations hint at a role for phase II enzymes in the evolution of such conditions. Furthermore, promising findings reveal that overexpression of phase II genes, either by genetic or chemical approaches, confers neuroprotection in vitro and in vivo. Therefore, there is a need to summarize the current literature on phase II genes in the central nervous system (CNS). This should help guide future studies on phase II genes as therapeutic targets in neurological diseases. In this review, we first briefly introduce the concept of phase I, II and III enzymes, with a special focus on phase II enzymes. We then discuss their expression regulati...Continue Reading

References

Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·Y ZhangG H Posner
Jan 15, 1993·Science·A VermaS H Snyder
Apr 1, 1994·The Tohoku Journal of Experimental Medicine·A KuwanoS Shibahara
Jan 1, 1993·Advances in Enzyme Regulation·T PresteraP Talalay
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y TakagiJ Yodoi
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·M T Smith
May 3, 2000·The European Journal of Neuroscience·E RybnikovaM Pelto-Huikko
Jul 25, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S OnoR L Macdonald
Oct 18, 2000·Proceedings of the National Academy of Sciences of the United States of America·H C HuangC B Pickett
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·M Ramos-GomezT W Kensler
Jul 10, 2001·Annual Review of Biophysics and Biomolecular Structure·G Powis, W R Montfort
Dec 26, 2001·The Journal of Biological Chemistry·Tsugunobu AndohChuang Chin Chiueh
Jun 18, 2002·Journal of Neurosurgery·Shigeki OnoR Loch Macdonald
Jul 30, 2002·The Journal of Biological Chemistry·Laurie M Zipper, R Timothy Mulcahy
Oct 3, 2002·Annual Review of Pharmacology and Toxicology·Truyen NguyenCecil B Pickett
Oct 9, 2002·Current Drug Metabolism·Thomas H Rushmore, A-N Tony Kong
Mar 21, 2003·The Journal of Biological Chemistry·Robert ElsbyB Kevin Park
Mar 26, 2003·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Ken ItohMasayuki Yamamoto
Apr 18, 2003·American Journal of Physiology. Cell Physiology·Satoshi NumazawaTakemi Yoshida
Oct 1, 2003·Molecular and Cellular Biology·Sara B CullinanJ Alan Diehl
Nov 1, 2003·Science·Ted M Dawson, Valina L Dawson
Jan 30, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jiying SunKazuhiko Igarashi
Feb 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nobunao WakabayashiPaul Talalay
Feb 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Moon-Il KangMasayuki Yamamoto
Dec 14, 2004·The Journal of Biological Chemistry·Hyun Ae WooSue Goo Rhee
Dec 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·Marcus J CalkinsJeffrey A Johnson
Jan 5, 2005·Free Radical Biology & Medicine·Hye-Youn ChoSteven R Kleeberger

❮ Previous
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Citations

Mar 28, 2013·Oxidative Medicine and Cellular Longevity·Wei WuDonna D Zhang
Mar 29, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Rafal M KaminskiHenrik Klitgaard
Jan 15, 2014·Journal of Physiology and Biochemistry·Monika SobczakLudmila Zylinska
Nov 12, 2013·Antioxidants & Redox Signaling·Zeynab NayerniaKarl-Heinz Krause
Sep 12, 2014·Neurochemical Research·Huizhen GuoXiaoping Lai
Sep 26, 2013·The International Journal of Neuroscience·Huaxing MengJin Zhang
Sep 15, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jong-Hyun ParkKi Duk Park
Jul 26, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dong-Sung LeeGil-Saeng Jeong
Jul 22, 2015·Biological Trace Element Research·Xiaojie ZhangYinping Huang
Feb 6, 2016·Molecular Neurobiology·Shuai JiangYang Yang
Jul 15, 2015·Free Radical Biology & Medicine·Katja M KanninenAnna-Liisa Levonen
Feb 18, 2016·Journal of Diabetes Research·Xue Cai, James F McGinnis
Dec 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Yanhong WeiElia J Duh
Jul 15, 2015·Free Radical Biology & Medicine·A L DafreP Maher
May 21, 2013·Annals of Neurology·Manuela MazzuferiRafal M Kaminski
Apr 23, 2014·Stem Cells·Virve KärkkäinenJari Koistinaho
Feb 12, 2015·Clinical Pharmacology and Therapeutics·D S Miller
Sep 22, 2015·Frontiers in Cellular Neuroscience·Iva BozicIrena Lavrnja
Aug 19, 2015·Neurochemistry International·Mary S LopezRaghu Vemuganti
Sep 25, 2015·Cellular and Molecular Neurobiology·Reddemma SandireddyAshutosh Kumar
Sep 18, 2015·Journal of Neuroinflammation·Antwoine FlowersPaula C Bickford
Jan 6, 2015·Journal of Cellular Physiology·Chao-Hung YehSheau-Huei Chueh
Dec 22, 2014·Molecular and Cellular Endocrinology·Jerry Vriend, Russel J Reiter
Jul 17, 2015·Oxidative Medicine and Cellular Longevity·Mika ReinisaloReijo O Karjalainen
Dec 3, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Krishnendu SinhaParames C Sil
Oct 1, 2013·Progress in Neurobiology·Sheng ChenJohn H Zhang

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