Emerging roles of RNA modifications in bacteria

Current Opinion in Microbiology
Carmelita Nora Marbaniang, Jörg Vogel

Abstract

RNA modifications are known to abound in stable tRNA and rRNA, where they cluster around functionally important regions. However, RNA-seq based techniques profiling entire transcriptomes are now uncovering an abundance of modified ribonucleotides in mRNAs and noncoding RNAs, too. While most of the recent progress in understanding the regulatory influence of these new RNA modifications stems from eukaryotes, there is growing evidence in bacteria for modified nucleotides beyond the stable RNA species, including modifications of small regulatory RNAs. Given their small genome size, good genetic tractability, and ample knowledge of modification enzymes, bacteria offer excellent model systems to decipher cellular functions of RNA modifications in many diverse physiological contexts. This review highlights how new global approaches combining classic analysis with new sequencing techniques may usher in an era of bacterial epitranscriptomics.

References

Jul 2, 1979·Molecular & General Genetics : MGG·B K Ray, D Apirion
Sep 1, 1990·Molecular Microbiology·D H Bechhofer
Jul 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y Liu, D V Santi
Jul 21, 2000·IUBMB Life·M Charette, M W Gray
Nov 30, 2005·Methods : a Companion to Methods in Enzymology·Jernej UleRobert B Darnell
May 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Walter E KowtoniukDavid R Liu
Oct 13, 2009·Nature Chemical Biology·Y Grace ChenDavid R Liu
Jun 4, 2010·Nature Reviews. Molecular Cell Biology·Joel G Belasco
Nov 13, 2010·Nucleic Acids Research·William A CantaraPaul F Agris
Dec 28, 2010·Cell·Robert J NicholsCarol A Gross
May 28, 2011·Accounts of Chemical Research·Chengqi Yi, Tao Pan
Apr 1, 1997·Analytical Chemistry·A ApffelW S Hancock
Feb 22, 2012·Nucleic Acids Research·Jeffrey E SquiresThomas Preiss
Nov 3, 2012·Nucleic Acids Research·Magdalena A MachnickaHenri Grosjean
Apr 23, 2013·Nature Biotechnology·Vahid Khoddami, Bradley R Cairns
Oct 24, 2013·RNA·Paul RyvkinLi-San Wang
Nov 30, 2013·Genome Biology·Shobbir HussainMichaela Frye
Jan 11, 2014·Genome Research·Masayuki SakuraiTsutomu Suzuki
Apr 10, 2014·Nature Reviews. Molecular Cell Biology·Kate D Meyer, Samie R Jaffrey
Sep 19, 2014·RNA·Xinguo ChenSandra L Wolin
Jan 13, 2015·Nucleic Acids Research·Robert S IllingworthAdrian P Bird
Mar 17, 2015·Nature Structural & Molecular Biology·Yury S PolikanovThomas A Steitz
May 13, 2015·Molecular Therapy. Nucleic Acids·Breanne LandryHasan Uludag
Jun 13, 2015·Nucleic Acids Research·Xin DengChuan He
Sep 15, 2015·Nucleic Acids Research·Ralf HauenschildMark Helm
Nov 26, 2015·Cell·Kate D MeyerSamie R Jaffrey

❮ Previous
Next ❯

Citations

May 25, 2016·RNA Biology·Alice Lebreton, Pascale Cossart
Jul 19, 2016·Nature Chemical Biology·Katharina HöferAndres Jäschke
Jan 21, 2017·Journal of the American Society for Mass Spectrometry·Mellie June Paulines, Patrick A Limbach
Mar 23, 2017·Biomolecules·Chenkang ZhengPatricia C Dos Santos
Feb 1, 2017·Microbiology·Kathrin BaumgardtElena Evguenieva-Hackenberg
May 13, 2017·Cell Death and Differentiation·Mariavittoria PizzingaAnne E Willis
Jun 20, 2017·Archives of Biochemistry and Biophysics·Murielle Lombard, Djemel Hamdane
Jul 12, 2018·Nature Reviews. Microbiology·Erik Holmqvist, Jörg Vogel
Oct 3, 2018·Wiley Interdisciplinary Reviews. RNA·Nikita VasilyevAlexander Serganov
Oct 6, 2017·FEMS Microbiology Reviews·Brice Felden, Luc Paillard
Nov 20, 2019·Antimicrobial Agents and Chemotherapy·Dipannita GhoshPerumal Vivekanandan
Apr 2, 2020·Biomolecules·Florian AbeleAndres Jäschke
Apr 16, 2020·BMC Biology·Ulrike SchumannThomas Preiss
Jun 3, 2016·Clinical Science·Charles J DormanMatthew J Dorman
Aug 28, 2020·Wiley Interdisciplinary Reviews. RNA·Mikel Irastortza-Olaziregi, Orna Amster-Choder
Oct 6, 2018·FEMS Microbiology Reviews·Lianrong WangShi Chen
Dec 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marvin MöhlerAndres Jäschke
Feb 19, 2021·Nature Reviews. Genetics·Alexander J Westermann, Jörg Vogel
Mar 10, 2020·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·Philip P Adams, Gisela Storz
Apr 18, 2019·Biochimie·Maxence LejarsEliane Hajnsdorf
Jun 20, 2018·Microbiology Spectrum·Katharina Höfer, Andres Jäschke
Sep 3, 2021·Seminars in Cancer Biology·Jurandir Cruz, Bernardo Lemos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.