Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications

International Journal of Cancer. Journal International Du Cancer
William Ka Kei WuChi H Cho


Human cathelicidin LL-37, a host defense peptide derived from leukocytes and epithelial cells, plays a crucial role in innate and adaptive immunity. Not only does LL-37 eliminate pathogenic microbes directly but also modulates host immune responses. Emerging evidence from tumor biology studies indicates that LL-37 plays a prominent and complex role in carcinogenesis. Although overexpression of LL-37 has been implicated in the development or progression of many human malignancies, including breast, ovarian and lung cancers, LL-37 suppresses tumorigenesis in gastric cancer. These data are beginning to unveil the intricate and contradictory functions of LL-37. The reasons for the tissue-specific function of LL-37 in carcinogenesis remain to be elucidated. Here, we review the relationship between LL-37, its fragments and cancer progression as well as discuss the potential therapeutic implications of targeting this peptide.


Mar 7, 1998·The Journal of Biological Chemistry·J JohanssonBirgitta Agerberth
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·Robert BalsJ M Wilson
Feb 27, 2001·FEBS Letters·J Bartek, J Lukas
Sep 13, 2002·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Mohamed Zaiou, Richard L Gallo
Jun 5, 2003·The Journal of Clinical Investigation·Rembert KoczullaRobert Bals
Jun 5, 2003·The Journal of Clinical Investigation·I R GarrettG R Mundy
Dec 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·G S TjabringaP S Hiemstra
Jan 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael D HowellDonald Y M Leung
Mar 9, 2004·Biochemical and Biophysical Research Communications·Xian-Zi WenY Yuasa
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andreas ElssnerMark D Wewers
Dec 21, 2004·International Journal of Cancer. Journal International Du Cancer·Johan D HeilbornM Ståhle
Jun 21, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Renat ShaykhievRobert Bals
Jun 29, 2005·The Journal of Investigative Dermatology·Belén López-GarcíaRichard L Gallo
Aug 27, 2005·Oncogene·Alison C Varga, Jeffrey L Wrana
Sep 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sho TokumaruKoji Hashimoto
Feb 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Neeloffer MookherjeeRobert E W Hancock
Mar 25, 2006·International Archives of Allergy and Immunology·G S TjabringaP S Hiemstra
Jul 25, 2006·Expert Opinion on Investigational Drugs·Jamie S Mader, David W Hoskin
Nov 7, 2006·Trends in Cell Biology·Bryan Linggi, Graham Carpenter
Sep 4, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Judith von HaussenRobert Bals
Oct 5, 2007·Nature·Antoine E KarnoubRobert A Weinberg
Oct 26, 2007·International Journal of Cancer. Journal International Du Cancer·Seth B CoffeltAline B Scandurro
Mar 14, 2008·Current Protein & Peptide Science·Guangshun Wang
Apr 26, 2008·Biochemical and Biophysical Research Communications·William Ka Kei WuChi Hin Cho
Sep 13, 2008·Cell Stem Cell·Mihaela CrisanBruno Péault
Oct 30, 2008·Nucleic Acids Research·Guangshun WangZhe Wang
Nov 14, 2008·Journal of Cellular Physiology·Marlon R Schneider, Eckhard Wolf
Nov 22, 2008·The Journal of Pathology·A I Caplan
Jan 28, 2009·Nature Reviews. Immunology·Antonio UccelliVito Pistoia
Feb 3, 2009·Breast Cancer Research : BCR·Günther WeberM Ståhle
Feb 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Seth B CoffeltAline B Scandurro
Jul 8, 2009·Antimicrobial Agents and Chemotherapy·Raquel F EpandRichard M Epand
Aug 5, 2009·The Journal of Clinical Investigation·Sophie Paquet-FifieldPritinder Kaur
Nov 20, 2009·The FEBS Journal·Tetsuya Mitsudomi, Yasushi Yatabe
Dec 2, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amanda S BüchauRichard L Gallo
Jan 1, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Plinio Hurtado, Chen Au Peh


May 21, 2013·World Journal of Gastroenterology : WJG·Jimmy Yip Chuen ChowChi Hin Cho
Dec 18, 2013·Future Microbiology·Peter G BarlowDonald J Davidson
May 16, 2014·Pharmaceuticals·Guangshun Wang
Sep 24, 2015·Archivum Immunologiae Et Therapiae Experimentalis·Ewelina PiktelRobert Bucki
Jul 28, 2015·Peptides·João Pinto da CostaRui Vitorino
Sep 17, 2011·Medicinal Research Reviews·Frederick HarrisDavid A Phoenix
Nov 12, 2015·Biochimica Et Biophysica Acta·Daniela XhindoliAlessandro Tossi
Jan 17, 2015·Applied Microbiology and Biotechnology·Margot SchlusselhuberJean-Marc Berjeaud
Dec 19, 2012·Cellular Immunology·Dieter VandammeLiliane Schoofs
Oct 6, 2015·BioFactors·Katarzyna BandurskaPiotr Krupa
May 3, 2016·Inflammatory Bowel Diseases·Lihua SunHua Yang
May 9, 2018·Journal of Peptide Science : an Official Publication of the European Peptide Society·Paola SaporitoHåvard Jenssen
Aug 22, 2014·Nature Chemistry·Alan D FaulknerPeter Scott
Nov 30, 2012·Biopolymers·Osmar N SilvaOctavio L Franco
Aug 24, 2018·Biomolecules·Fatma Gizem AvciElif Ozkirimli
Jun 15, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·M Dolores SalvadoJesper Z Haeggström
Jun 16, 2012·Journal of Leukocyte Biology·Anne M van der DoesLennart Lindbom
Jan 18, 2020·Haematologica·Enrique PodazaMirta Giordano
Jul 26, 2018·Vaccines·Maelíosa T C McCruddenFionnuala T Lundy
Feb 20, 2019·Frontiers in Chemistry·Evan F HaneyRobert E W Hancock
Jun 26, 2020·Frontiers in Immunology·Maaike R ScheenstraMaarten Coorens
Apr 14, 2018·International Journal of Molecular Sciences·Liling ZhaoYaoqi Zhou
Feb 29, 2020·Nature Reviews. Drug Discovery·Neeloffer MookherjeeDonald J Davidson
Jun 9, 2020·BioMed Research International·Binbin YangMing Q Wei

Related Concepts

ALL-38 peptide
Malignant Neoplasms
Amphipathic Cationic Antimicrobial Peptides
Malignant Neoplasms
Epithelial Cells
Malignant Neoplasm of Stomach

Related Feeds

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Related Papers

The Prostate
Jonathan A HenselSelvarangan Ponnazhagan
Archivum Immunologiae Et Therapiae Experimentalis
Robert BuckiWojciech Sokołowski
Journal of the European Academy of Dermatology and Venereology : JEADV
T F LeungK L Hon
© 2021 Meta ULC. All rights reserved